223185

• Gene Symbol: Dab2ip
• Gene Name: disabled 2 interacting protein
• Gene Aliases: 2310011D08Rik, AI480459, Aip1, mKIAA1743
• Chromosome Location: Chr.2: 35558458 - 35730994 on Build GRCm38
• UniGene ID: Mm.29629
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Dab2ip
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001001602.2	NP_001001602.2	14	3603
	NM_001114124.2	NP_001107596.1	16	3727
	NM_001290639.1	NP_001277568.1	14	3262
	NM_001290640.1	NP_001277569.1	14	3567
	NM_001290641.1	NP_001277570.1	16	3860
GenBank mRNA	AK122548.1	-	10	2414
	AK147464.1	-	16	3659
	AK147593.1	-	16	3861
	AY305656.1	-	14	3320
	AY305657.1	-	14	3603
	AY305658.1	-	14	3262
	BC118530.1	-	14	3228	40098202

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_138709, AY032952.
This siRNA also targets the following transcripts in Rat: NM_138710, XM_006234057, XM_008761698, XM_008761697, BC061865, and others.

Panther Classification:

Molecular Function -

GTPase-activating protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPKKK activity
angiogenesis
negative regulation of protein phosphorylation
immune system process
apoptotic process
inflammatory response
response to unfolded protein
cell cycle
signal transduction
I-kappaB phosphorylation
activation of JUN kinase activity
multicellular organism development
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell migration
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
positive regulation of neuron projection development
negative regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
cell motility involved in cerebral cortex radial glia guided migration
layer formation in cerebral cortex
negative regulation of cell growth
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of GTPase activity
tube formation
negative regulation of catenin import into nucleus
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
reelin-mediated signaling pathway
regulation of growth
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
regulation of GTPase activity
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of MAP kinase activity
positive regulation of MAPK cascade
regulation of protein heterodimerization activity
positive regulation of JUN kinase activity
positive regulation of GTPase activity
negative regulation of phosphatidylinositol 3-kinase activity
cellular protein catabolic process
innate immune response
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of Ras protein signal transduction
negative regulation of fibroblast proliferation
neuron projection morphogenesis
negative regulation of epithelial cell proliferation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of G0 to G1 transition
negative regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle arrest
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
negative regulation of protein serine/threonine kinase activity
positive regulation of protein serine/threonine kinase activity
negative regulation of canonical Wnt signaling pathway
positive regulation of synapse maturation
positive regulation of dendrite development
regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of proteasomal protein catabolic process
negative regulation of cyclin catabolic process
positive regulation of neuron migration
positive regulation of apoptotic signaling pathway

Function(s)

GTPase activator activity
death receptor binding
protein binding
SH3 domain binding
kinase binding
protein kinase binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
phosphatidylinositol-3-phosphate binding
protein complex binding
signaling adaptor activity
Toll-like receptor 4 binding
phosphatidylinositol 3-kinase regulatory subunit binding
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 2 binding
phosphatidylinositol 3-kinase binding
protein N-terminus binding
protein phosphatase 2A binding
phosphatidylinositol-4-phosphate binding
14-3-3 protein binding