235613

• Gene Symbol: ELANE
• Gene Name: elastase, neutrophil expressed
• Gene Aliases: ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
• Chromosome Location: Chr.19: 850997 - 856250 on Build GRCh38
• UniGene ID: Hs.99863
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ELANE
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001972.3	NP_001963.1	5	846
	XM_011527775.1	XP_011526077.1	6	1523
	XM_011527776.1	XP_011526078.1	6	862
GenBank mRNA	BC074816.2	-	5	763	30915534
	BC074817.2	-	5	763	30915320
	D00187.1	-	4	636
	J03545.1	-	3	504
	M27783.1	-	2	360
	M34379.1	-	5	764
	X05875.1	-	5	764

More Information

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
response to yeast
acute inflammatory response to antigenic stimulus
proteolysis
cellular calcium ion homeostasis
phagocytosis
response to UV
extracellular matrix disassembly
protein catabolic process
response to lipopolysaccharide
defense response to bacterium
positive regulation of MAP kinase activity
negative regulation of growth of symbiont in host
negative regulation of chemokine biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of immune response
leukocyte migration
negative regulation of chemotaxis
neutrophil mediated killing of fungus

Function(s)

RNA polymerase II transcription corepressor activity
protease binding
endopeptidase activity
serine-type endopeptidase activity
protein binding
heparin binding
peptidase activity
cytokine binding