24947

• Gene Symbol: NOTCH1
• Gene Name: notch 1
• Gene Aliases: AOS5, AOVD1, TAN1, hN1
• Chromosome Location: Chr.9: 136494433 - 136545786 on Build GRCh38
• UniGene ID: Hs.495473
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NOTCH1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_017617.4	NP_060087.3	5	773
	XM_011518717.2	XP_011517019.2	2	65
GenBank mRNA	AF308602.1	-	5	773
	CN431067.1	-	1	16
	M73980.1	-	5	773

More Information

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
cell fate specification
epithelial to mesenchymal transition
liver development
heart looping
sprouting angiogenesis
positive regulation of neuroblast proliferation
inflammatory response to antigenic stimulus
endocardium development
endocardium morphogenesis
atrioventricular node development
coronary vein morphogenesis
aortic valve morphogenesis
atrioventricular valve morphogenesis
pulmonary valve morphogenesis
mitral valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac chamber formation
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
cardiac right atrium morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle formation
ventricular trabecula myocardium morphogenesis
growth involved in heart morphogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
cell migration involved in endocardial cushion formation
pericardium morphogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
immune response
humoral immune response
Notch signaling pathway
positive regulation of transcription of Notch receptor target
spermatogenesis
determination of left/right symmetry
compartment pattern specification
axonogenesis
foregut morphogenesis
endoderm development
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
auditory receptor cell fate commitment
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
negative regulation of myotube differentiation
mesenchymal cell development
regulation of somitogenesis
cell differentiation in spinal cord
neural tube development
keratinocyte differentiation
negative regulation of ossification
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
hair follicle morphogenesis
organ regeneration
response to corticosteroid
response to muramyl dipeptide
response to lipopolysaccharide
embryonic hindlimb morphogenesis
tube formation
skeletal muscle cell differentiation
cellular response to vascular endothelial growth factor stimulus
tissue regeneration
positive regulation of apoptotic process
negative regulation of catalytic activity
positive regulation of viral genome replication
positive regulation of endothelial cell differentiation
negative regulation of auditory receptor cell differentiation
positive regulation of keratinocyte differentiation
negative regulation of myoblast differentiation
negative regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of calcium ion-dependent exocytosis
positive regulation of JAK-STAT cascade
negative regulation of photoreceptor cell differentiation
somatic stem cell division
astrocyte differentiation
oligodendrocyte differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
branching morphogenesis of an epithelial tube
positive regulation of viral transcription
positive regulation of epithelial cell proliferation
negative regulation of neurogenesis
cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
negative regulation of glial cell proliferation
cilium morphogenesis
cardiac epithelial to mesenchymal transition
cardiac septum morphogenesis
ventricular septum morphogenesis
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
prostate gland epithelium morphogenesis
regulation of epithelial cell proliferation involved in prostate gland development
arterial endothelial cell differentiation
venous endothelial cell differentiation
cardiac vascular smooth muscle cell development
endocardial cell differentiation
vasculogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
Notch signaling involved in heart development
heart trabecula morphogenesis
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
left/right axis specification
cellular response to follicle-stimulating hormone stimulus
distal tubule development
collecting duct development
glomerular mesangial cell development
interleukin-4 secretion
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
regulation of extracellular matrix assembly
apoptotic process involved in embryonic digit morphogenesis
negative regulation of stem cell differentiation
negative regulation of anoikis
negative regulation of pro-B cell differentiation
negative regulation of endothelial cell chemotaxis

Function(s)

core promoter binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
enzyme inhibitor activity
receptor activity
Notch binding
calcium ion binding
protein binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
protein heterodimerization activity