2600

• Gene Symbol: STAT1
• Gene Name: signal transducer and activator of transcription 1
• Gene Aliases: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
• Chromosome Location: Chr.2: 190969036 - 191014250 on Build GRCh38
• UniGene ID: Hs.642990
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: STAT1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_007315.3	NP_009330.1	4	647
	NM_139266.2	NP_644671.1	4	647
	XM_006712718.1	XP_006712781.1	3	440
	XM_017004783.1	XP_016860272.1	5	677
GenBank mRNA	AK096686.1	-	5	664
	AK225853.1	-	4	625
	AK292604.1	-	3	691
	AK315002.1	-	4	562
	BC002704.2	-	4	565	3627218
	BT007241.1	-	2	259
	CR749636.1	-	4	554
	CR998778.1	-	4	607
	GU211347.1	-	3	323
	GU211348.1	-	3	323
	M97935.1	-	3	455
	M97936.1	-	3	455

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_032612, NM_001034164, BC062079, CV075250, AF205604.

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
negative regulation of endothelial cell proliferation
positive regulation of mesenchymal cell proliferation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
apoptotic process
JAK-STAT cascade
blood circulation
macrophage derived foam cell differentiation
negative regulation of angiogenesis
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to interferon-beta
cellular response to interferon-beta
regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to peptide hormone
endothelial cell migration
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
response to cAMP
defense response to virus
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
renal tubule development
cellular response to organic cyclic compound
metanephric mesenchymal cell proliferation involved in metanephros development
metanephric mesenchymal cell differentiation
negative regulation of metanephric nephron tubule epithelial cell differentiation
cell-cell adhesion

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
tumor necrosis factor receptor binding
protein binding
enzyme binding
nuclear hormone receptor binding
identical protein binding
protein homodimerization activity
cadherin binding involved in cell-cell adhesion