261060

• Gene Symbol: Hand2
• Gene Name: heart and neural crest derivatives expressed transcript 2
• Gene Aliases: AI225906, AI661148, Ehand2, Hed, Th2, Thing2, bHLHa26, dHAND
• Chromosome Location: Chr.8: 57320983 - 57324517 on Build GRCm38
• UniGene ID: Mm.430844
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hand2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010402.4	NP_034532.3	1	1450
GenBank mRNA	AJ131846.1	-	1	531
	AK035160.1	-	1	1452

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_021973, BC101406, BC109383, AF087940, BF313018, and others.
This siRNA also targets the following transcripts in Rat: NM_022696, Y08138.

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

angiogenesis
in utero embryonic development
heart looping
suckling behavior
heart morphogenesis
cardiac right ventricle formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
apoptotic process involved in heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
heart development
adult heart development
mesenchymal cell proliferation
negative regulation of cardiac muscle cell apoptotic process
neural crest cell development
cell differentiation
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
tongue development
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
thymus development
peripheral nervous system neuron development
palate development
mesenchyme development
cartilage morphogenesis
coronary artery morphogenesis
visceral serous pericardium development
cardiac neural crest cell development involved in outflow tract morphogenesis
cell proliferation involved in outflow tract morphogenesis
determination of heart left/right asymmetry
positive regulation of transcription regulatory region DNA binding
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
AT DNA binding
transcription coactivator activity
protein binding
transcription factor binding
activating transcription factor binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
protein dimerization activity
E-box binding