263231

• Gene Symbol: TERT
• Gene Name: telomerase reverse transcriptase
• Gene Aliases: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
• Chromosome Location: Chr.5: 1253167 - 1295626 on Build GRCh38
• UniGene ID: Hs.492203
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TERT
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001193376.1	NP_001180305.1	3	1731
	NM_198253.2	NP_937983.2	3	1731
	XM_017009796.1	XP_016865285.1	3	2303
GenBank mRNA	AB085628.1	-	3	1673
	AB086379.1	-	3	1673
	AB086950.1	-	3	1673
	AF015950.1	-	3	1728
	AF018167.1	-	3	1729
	AX810036.1	-	3	1728
	AX810378.1	-	3	1728
	BC062321.1	-	1	486
	JF896280.1	-	2	342
	JF896282.1	-	1	47
	JF896285.1	-	1	59

More Information

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

telomere maintenance
transcription, RNA-templated
RNA-dependent DNA biosynthetic process
telomere maintenance via telomerase
mitochondrion organization
negative regulation of gene expression
DNA strand elongation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
positive regulation of protein binding
RNA biosynthetic process
positive regulation of hair cycle
positive regulation of nitric-oxide synthase activity
establishment of protein localization to telomere
cellular response to hypoxia
DNA biosynthetic process
replicative senescence
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of production of siRNA involved in RNA interference
positive regulation of protein localization to nucleolus
beta-catenin-TCF complex assembly
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

tRNA binding
transcription coactivator binding
DNA binding
telomerase activity
telomerase RNA reverse transcriptase activity
RNA binding
RNA-directed DNA polymerase activity
RNA-directed RNA polymerase activity
protein binding
nucleotidyltransferase activity
telomeric DNA binding
protein homodimerization activity
metal ion binding
telomerase RNA binding