2758

• Gene Symbol: TP73
• Gene Name: tumor protein p73
• Gene Aliases: P73
• Chromosome Location: Chr.1: 3652565 - 3736201 on Build GRCh38
• UniGene ID: Hs.192132
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TP73
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001126240.2	NP_001119712.1	11	1632
	NM_001126242.2	NP_001119714.1	10	1483
	NM_001204185.1	NP_001191114.1	12	1506
	NM_001204188.1	NP_001191117.1	11	1367
	NM_001204191.1	NP_001191120.1	9	1344
	NM_001204192.1	NP_001191121.1	11	1465
	NM_005427.3	NP_005418.1	13	1655
GenBank mRNA	AB055065.1	-	11	1632
	AK295669.1	-	5	704
	AK302118.1	-	11	1453
	AK304784.1	-	11	1582
	AY040827.1	-	11	1632
	AY040829.1	-	10	1483
	BC117251.1	-	13	1655	40125802
	BC117253.1	-	13	1655	40125804
	Y11416.1	-	13	1655

More Information

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
kidney development
mismatch repair
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
regulation of mitotic cell cycle
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to organonitrogen compound
response to gamma radiation
regulation of gene expression
viral process
mitotic G1 DNA damage checkpoint
cellular response to UV
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
negative regulation of JUN kinase activity
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of oligodendrocyte differentiation
protein tetramerization
negative regulation of cardiac muscle cell proliferation
positive regulation of cell cycle arrest
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
chromatin binding
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding