2795

• Gene Symbol: MSH2
• Gene Name: mutS homolog 2
• Gene Aliases: COCA1, FCC1, HNPCC, HNPCC1, LCFS2
• Chromosome Location: Chr.2: 47403067 - 47634501 on Build GRCh38
• UniGene ID: Hs.597656
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MSH2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000251.2	NP_000242.1	2	463
	NM_001258281.1	NP_001245210.1	3	279
	XM_005264332.3	XP_005264389.2	2	410
	XM_011532867.1	XP_011531169.1	2	410
GenBank mRNA	AK222860.1	-	2	400
	AK223284.1	-	2	373
	AK299667.1	-	1	97
	AK304496.1	-	3	279
	AK311330.1	-	2	349
	BC001122.1	-	2	341
	BC021566.1	-	2	352	4110354
	BX649122.1	-	2	358
	DC342099.1	-	2	463
	DQ648894.1	-	2	325
	L47574.1	-	2	378
	L47575.1	-	2	378
	L47576.1	-	2	378
	L47577.1	-	2	378
	L47578.1	-	2	378
	L47579.1	-	2	378
	L47580.1	-	2	378
	L47581.1	-	2	378
	L47582.1	-	2	378
	L47583.1	-	2	378
	U03911.1	-	2	341
	U04045.1	-	2	406

More Information

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

meiotic mismatch repair
in utero embryonic development
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
meiotic gene conversion
cell cycle arrest
reciprocal meiotic recombination
germ cell development
determination of adult lifespan
male gonad development
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
negative regulation of reciprocal meiotic recombination
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity

Function(s)

magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
protein C-terminus binding
ATPase activity
centromeric DNA binding
enzyme binding
protein kinase binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding