287539

• Gene Symbol: Shank3
• Gene Name: SH3/ankyrin domain gene 3
• Gene Aliases: AI841104, SHANK3c-3, SHANK3c-4, Shank3b
• Chromosome Location: Chr.15: 89499707 - 89560261 on Build GRCm38
• UniGene ID: Mm.146855
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Shank3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_021423.3	NP_067398.2	21	4479
GenBank mRNA	AB231013.1	-	21	4479
	AB841411.1	-	11	3443
	AK173228.1	-	1	1858
	KF612595.1	-	1	27

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_033517, BC062987, AB569469, AK074038, AB051437.
This siRNA also targets the following transcripts in Rat: NM_021676, AJ133120, AF133301.

Gene Ontology Categories:

Process(es)

MAPK cascade
embryonic epithelial tube formation
synapse assembly
learning
memory
striatal medium spiny neuron differentiation
adult behavior
negative regulation of actin filament bundle assembly
social behavior
locomotory exploration behavior
vocal learning
negative regulation of cell volume
positive regulation of long-term neuronal synaptic plasticity
brain morphogenesis
neuromuscular process controlling balance
protein oligomerization
positive regulation of synapse structural plasticity
positive regulation of synaptic transmission, glutamatergic
dendritic spine morphogenesis
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
vocalization behavior
postsynaptic density assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
regulation of long-term synaptic potentiation
positive regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
regulation of long term synaptic depression
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
regulation of behavioral fear response
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Function(s)

actin binding
protein binding
protein C-terminus binding
zinc ion binding
SH3 domain binding
GKAP/Homer scaffold activity
ionotropic glutamate receptor binding
identical protein binding
protein self-association
scaffold protein binding