289435

• Gene Symbol: HMGA2
• Gene Name: high mobility group AT-hook 2
• Gene Aliases: BABL, HMGI-C, HMGIC, LIPO, STQTL9
• Chromosome Location: Chr.12: 65824460 - 65966291 on Build GRCh38
• UniGene ID: Hs.505924
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HMGA2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001300918.1	NP_001287847.1	3	1039
	NM_001300919.1	NP_001287848.1	3	1039
	NM_003483.4	NP_003474.1	3	1039
	NM_003484.1	NP_003475.1	3	1039
	XM_017019989.1	XP_016875478.1	3	688
GenBank mRNA	AB209853.1	-	3	601
	AF533651.1	-	2	103
	AF533652.1	-	2	137
	AF533653.1	-		131
	AF533654.1	-	2	131
	AI290477.1	-	2	117
	AY601861.1	-	3	1039
	AY601862.1	-	3	1039
	AY601863.1	-	3	1039
	AY601864.1	-	3	1039
	AY601865.1	-	3	1039
	AY601866.1	-	3	1039
	AY601867.1	-	3	1039
	U28749.1	-	3	1039
	X92518.1	-	3	1538
	Z31595.1	-	3	1040

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_032070, U89695.
This siRNA also targets the following transcripts in Mouse: NM_010441, BC052158, BC085085, BC069985, AK028346, and others.

Panther Classification:

Molecular Function -

endodeoxyribonuclease

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
chondrocyte differentiation
mesodermal-endodermal cell signaling
base-excision repair
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
mitotic G2 DNA damage checkpoint
multicellular organism development
response to virus
regulation of cell cycle process
positive regulation of gene expression
chromosome condensation
chromosome breakage
heterochromatin assembly
histone H2A-S139 phosphorylation
senescence-associated heterochromatin focus assembly
endodermal cell differentiation
chondrocyte proliferation
regulation of growth
DNA damage response, detection of DNA damage
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
fat cell differentiation
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
mesenchymal cell differentiation
stem cell differentiation
cell division
positive regulation of cell cycle arrest
oncogene-induced cell senescence
regulation of stem cell population maintenance
positive regulation of stem cell proliferation
positive regulation of transcription regulatory region DNA binding
positive regulation of cellular response to X-ray
positive regulation of cellular senescence
positive regulation of response to DNA damage stimulus
negative regulation of double-strand break repair via nonhomologous end joining
regulation of cellular response to drug

Function(s)

regulatory region DNA binding
transcription factor activity, transcription factor binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
AT DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
DNA-dependent protein kinase activity
protein binding
transcription factor binding
DNA binding, bending
nucleosomal DNA binding
cAMP response element binding
MH2 domain binding
MH1 domain binding
SMAD binding
5'-deoxyribose-5-phosphate lyase activity
C2H2 zinc finger domain binding