31

• Gene Symbol: INSR
• Gene Name: insulin receptor
• Gene Aliases: CD220, HHF5
• Chromosome Location: Chr.19: 7112255 - 7294405 on Build GRCh38
• UniGene ID: Hs.465744
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: INSR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000208.3	NP_000199.2	21	4151
	NM_001079817.2	NP_001073285.1	20	4115
	XM_011527988.2	XP_011526290.2	21	4251
	XM_011527989.2	XP_011526291.2	20	4214
GenBank mRNA	AB208861.1	-	13	2093
	AK300332.1	-	1	82
	BC117172.1	-	20	3737	40125723
	M10051.1	-	21	3878
	X02160.1	-	20	3752

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017071, XM_006248753, XM_006248752, KF112847, KF112848, and others.

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
carbohydrate metabolic process
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
epidermis development
male gonad development
response to manganese ion
regulation of hydrogen peroxide metabolic process
positive regulation of glycoprotein biosynthetic process
negative regulation of gene expression
response to activity
peptidyl-tyrosine phosphorylation
transformation of host cell by virus
signal transduction by protein phosphorylation
male sex determination
adrenal gland development
positive regulation of cell migration
exocrine pancreas development
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol
negative regulation of transporter activity
cellular response to insulin stimulus
response to vitamin D
response to testosterone
response to tumor necrosis factor
peptidyl-tyrosine autophosphorylation
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
regulation of embryonic development
positive regulation of glucose import
protein autophosphorylation
positive regulation of developmental growth
protein heterotetramerization
response to glucocorticoid
positive regulation of meiotic cell cycle
positive regulation of protein kinase B signaling
positive regulation of respiratory burst
cellular response to growth factor stimulus
regulation of female gonad development

Function(s)

protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
insulin-activated receptor activity
insulin-like growth factor receptor binding
protein binding
ATP binding
GTP binding
protein phosphatase binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
PTB domain binding