325 Validated

• Gene Symbol: MAP2K1
• Gene Name: mitogen-activated protein kinase kinase 1
• Gene Aliases: CFC3, MAPKK1, MEK1, MKK1, PRKMK1
• Chromosome Location: Chr.15: 66386873 - 66491544 on Build GRCh38
• UniGene ID: Hs.145442
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MAP2K1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002755.3	NP_002746.1	11	1927
	XM_011521783.2	XP_011520085.1	11	1584
	XM_017022411.1	XP_016877900.1	10	1800
	XM_017022412.1	XP_016877901.1	10	1386
	XM_017022413.1	XP_016877902.1	7	1995
GenBank mRNA	AK291500.1	-	11	1888
	AK294322.1	-	11	1438
	BC139729.1	-	11	1511	40053655
	L11284.1	-	11	1524

More Information

Matching Taqman Gene Expression Assay:

Hs00605615_mH

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
movement of cell or subcellular component
chemotaxis
cell cycle arrest
signal transduction
heart development
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
peptidyl-tyrosine phosphorylation
cerebellar cortex formation
neuron differentiation
keratinocyte differentiation
thyroid gland development
regulation of stress-activated MAPK cascade
proteolysis in other organism
positive regulation of transcription, DNA-templated
thymus development
regulation of axon regeneration
cell motility
positive regulation of axonogenesis
Bergmann glial cell differentiation
face development
trachea formation
epithelial cell proliferation involved in lung morphogenesis
placenta blood vessel development
labyrinthine layer development
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
mitophagy in response to mitochondrial depolarization
positive regulation of production of miRNAs involved in gene silencing by miRNA
regulation of early endosome to late endosome transport

Function(s)

protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
receptor signaling protein tyrosine phosphatase activity
protein binding
ATP binding
protein C-terminus binding
protein kinase binding
protein serine/threonine kinase activator activity
protein N-terminus binding