329

• Gene Symbol: EIF2AK2
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 2
• Gene Aliases: EIF2AK1, PKR, PPP1R83, PRKR
• Chromosome Location: Chr.2: 37099210 - 37157065 on Build GRCh38
• UniGene ID: Hs.131431
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EIF2AK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001135651.2	NP_001129123.1	3	394
	NM_001135652.2	NP_001129124.1	1	87
	NM_002759.3	NP_002750.1	3	628
	XM_011532987.2	XP_011531289.1	3	328
	XM_017004503.1	XP_016859992.1	3	324
GenBank mRNA	AK290655.1	-	3	314
	AK313818.1	-	2	151
	AY302136.1	-	1	71
	BC007769.2	-	2	170
	BC022314.1	-	3	282
	BC040851.1	-	3	394
	BC057805.1	-	3	299
	BC093676.1	-	1	99	7939521
	BC101475.1	-	1	99	8068981
	BC143228.1	-	1	98
	BC143230.1	-	1	99	9051731
	M35663.1	-	2	257
	M85294.1	-	1	101

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
positive regulation of cytokine production
transcription, DNA-templated
translation
protein phosphorylation
negative regulation of cell proliferation
response to mechanical stimulus
response to virus
response to toxic substance
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
peptidyl-tyrosine phosphorylation
evasion or tolerance by virus of host immune response
endoplasmic reticulum unfolded protein response
response to lipopolysaccharide
positive regulation of chemokine production
positive regulation of stress-activated MAPK cascade
response to vitamin E
negative regulation of osteoblast proliferation
regulation of protein phosphatase type 2A activity
cellular response to amino acid starvation
response to interferon-alpha
positive regulation of apoptotic process
negative regulation of apoptotic process
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
defense response to virus
regulation of NLRP3 inflammasome complex assembly
positive regulation of NIK/NF-kappaB signaling
regulation of hematopoietic progenitor cell differentiation
regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell differentiation

Function(s)

double-stranded RNA binding
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
protein phosphatase type 2A regulator activity
poly(A) RNA binding