3347

• Gene Symbol: NFE2L2
• Gene Name: nuclear factor, erythroid 2 like 2
• Gene Aliases: HEBP1, NRF2
• Chromosome Location: Chr.2: 177230303 - 177265131 on Build GRCh38
• UniGene ID: Hs.744006
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NFE2L2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001145412.3	NP_001138884.1	5	2322
	NM_001145413.3	NP_001138885.1	5	2301
	NM_001313900.1	NP_001300829.1	5	2196
	NM_001313901.1	NP_001300830.1	5	2288
	NM_001313902.1	NP_001300831.1	4	2103
	NM_001313903.1	NP_001300832.1	5	1974
	NM_001313904.1	NP_001300833.1	5	2251
	NM_006164.4	NP_006155.2	5	2193
GenBank mRNA	AB208786.1	-	5	1704
	AK297838.1	-	5	1697
	AK304555.1	-	5	1742
	AK314816.1	-	5	2194
	AK316148.1	-	5	1645
	BC011558.1	-	5	1751	4548874
	BX649047.1	-	5	1732
	BX649071.1	-	4	1533
	HM446346.1	-	5	1645
	S74017.1	-	5	1629

More Information

Panther Classification:

Molecular Function -

basic leucine zipper transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
inflammatory response
proteasomal ubiquitin-independent protein catabolic process
positive regulation of gene expression
protein ubiquitination
positive regulation of blood coagulation
endoplasmic reticulum unfolded protein response
cellular response to oxidative stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
cell redox homeostasis
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
positive regulation of glucose import
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
negative regulation of hematopoietic stem cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of hydrogen peroxide-induced cell death
positive regulation of glutathione biosynthetic process
regulation of removal of superoxide radicals
negative regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
transcription regulatory region DNA binding