3359

• Gene Symbol: IRF3
• Gene Name: interferon regulatory factor 3
• Gene Aliases: IIAE7
• Chromosome Location: Chr.19: 49659569 - 49665875 on Build GRCh38
• UniGene ID: Hs.289052
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: IRF3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001197122.1	NP_001184051.1	2	405
	NM_001197124.1	NP_001184053.1	2	405
	NM_001571.5	NP_001562.1	2	405
	NR_045568.1		2	552
	XM_006723197.1	XP_006723260.1	2	383
	XM_006723198.1	XP_006723261.1	2	319
	XM_017026766.1	XP_016882255.1	2	374
	XM_017026767.1	XP_016882256.1	2	319
GenBank mRNA	AB102884.1	-	1	152
	AB102887.1	-	1	152
	AK057577.1	-	1	1171
	AK292027.1	-	2	534
	AK314421.1	-	2	318
	BC000660.2	-	2	307	3347928
	BC009395.2	-	2	332	4135383
	BC071721.1	-	1	494	5494536
	CB961512.1	-	2	413
	HM357936.1	-	2	235
	Z56281.1	-	2	198

More Information

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
lipopolysaccharide-mediated signaling pathway
negative regulation of type I interferon production
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
TRIF-dependent toll-like receptor signaling pathway
MDA-5 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
type I interferon biosynthetic process
positive regulation of cytokine secretion
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
cellular response to dsRNA
macrophage apoptotic process
programmed necrotic cell death

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription cofactor activity
protein binding
identical protein binding
protein homodimerization activity