3539

• Gene Symbol: ERCC3
• Gene Name: ERCC excision repair 3, TFIIH core complex helicase subunit
• Gene Aliases: BTF2, GTF2H, RAD25, TFIIH, TTD2, XPB
• Chromosome Location: Chr.2: 127257290 - 127294176 on Build GRCh38
• UniGene ID: Hs.469872
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ERCC3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000122.1	NP_000113.1	10	1761
	NM_001303416.1	NP_001290345.1	10	1876
	NM_001303418.1	NP_001290347.1	10	1938
	XM_011510794.1	XP_011509096.1	10	1740
	XM_011510795.1	XP_011509097.1	10	1614
	XM_017003583.1	XP_016859072.1	10	1596
GenBank mRNA	AK091500.1	-	10	1863
	AK095557.1	-	10	1938
	AK127469.1	-	6	3637
	AK222465.1	-	10	1728
	AK290474.1	-	10	1687
	BC008820.2	-	10	1730	3958781
	M31899.1	-	10	1761

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001031644, BC098856.
This siRNA also targets the following transcripts in Mouse: NM_133658, BC022956, AK160187, BC016595, BC024446, and others.

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA helicase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
protein localization
response to UV
UV protection
viral process
nucleotide-excision repair, DNA incision
hair cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition

Function(s)

DNA binding
damaged DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
protein binding
ATP binding
GTP binding
protein C-terminus binding
DNA-dependent ATPase activity
transcription factor binding
RNA polymerase II carboxy-terminal domain kinase activity
ATPase activity
dATP binding
peptide binding
3'-5' DNA helicase activity
protein N-terminus binding