37

• Gene Symbol: KIT
• Gene Name: KIT proto-oncogene receptor tyrosine kinase
• Gene Aliases: C-Kit, CD117, PBT, SCFR
• Chromosome Location: Chr.4: 54657928 - 54740715 on Build GRCh38
• UniGene ID: Hs.479754
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: KIT
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000222.2	NP_000213.1	21	3212
	NM_001093772.1	NP_001087241.1	21	3200
	XM_005265740.1	XP_005265797.1	21	3186
	XM_005265741.1	XP_005265798.1	21	3183
	XM_005265742.2	XP_005265799.1	21	3174
	XM_017008178.1	XP_016863667.1	21	3180
	XM_017008179.1	XP_016863668.1	21	3171
	XM_017008180.1	XP_016863669.1	21	3168
GenBank mRNA	AK304031.1	-	21	3171
	BC071593.1	-	21	3201	4375615
	HM015525.1	-	21	3118
	HM015526.1	-	21	3118
	X06182.1	-	21	3146

More Information

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
ovarian follicle development
myeloid progenitor cell differentiation
lymphoid progenitor cell differentiation
immature B cell differentiation
dendritic cell cytokine production
mast cell chemotaxis
glycosphingolipid metabolic process
inflammatory response
signal transduction
spermatogenesis
spermatid development
positive regulation of cell proliferation
germ cell migration
regulation of cell shape
visual learning
male gonad development
positive regulation of gene expression
positive regulation of phospholipase C activity
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
stem cell population maintenance
lamellipodium assembly
hemopoiesis
T cell differentiation
erythrocyte differentiation
melanocyte differentiation
positive regulation of cell migration
positive regulation of pseudopodium assembly
actin cytoskeleton reorganization
mast cell cytokine production
somatic stem cell population maintenance
embryonic hemopoiesis
ectopic germ cell programmed cell death
hematopoietic stem cell migration
megakaryocyte development
Fc receptor signaling pathway
Kit signaling pathway
erythropoietin-mediated signaling pathway
regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of programmed cell death
mast cell degranulation
positive regulation of MAPK cascade
pigmentation
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of Notch signaling pathway
positive regulation of JAK-STAT cascade
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
regulation of developmental pigmentation
somatic stem cell division
positive regulation of long-term neuronal synaptic plasticity
digestive tract development
stem cell differentiation
epithelial cell proliferation
detection of mechanical stimulus involved in sensory perception of sound
positive regulation of sequence-specific DNA binding transcription factor activity
cell chemotaxis
mast cell differentiation
mast cell proliferation
cellular response to thyroid hormone stimulus
melanocyte migration
melanocyte adhesion
positive regulation of vascular smooth muscle cell differentiation

Function(s)

protease binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
stem cell factor receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
cytokine binding
protein homodimerization activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity