388

• Gene Symbol: TGFBR2
• Gene Name: transforming growth factor beta receptor 2
• Gene Aliases: AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
• Chromosome Location: Chr.3: 30606490 - 30694142 on Build GRCh38
• UniGene ID: Hs.604277
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TGFBR2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001024847.2	NP_001020018.1	3	708
	NM_003242.5	NP_003233.4	2	633
	XM_011534043.2	XP_011532345.1	3	481
	XM_011534045.2	XP_011532347.1	2	261
	XM_017007106.1	XP_016862595.1	2	1847
GenBank mRNA	AK300383.1	-	3	609
	AK304404.1	-	3	377
	AK314102.1	-	2	549
	AL554950.3	-	2	645
	BC040499.1	-	2	634
	CB988859.1	-	3	636
	D28131.1	-	3	266
	KC792576.1	-	2	290
	KC792577.1	-	2	290
	KC792578.1	-	2	290
	KC792579.1	-	2	290
	KC792580.1	-	2	290
	KU178359.1	-	2	251
	KU178360.1	-	3	326
	M85079.1	-	2	586

More Information

Panther Classification:

Molecular Function -

serine/threonine protein kinase receptor

Gene Ontology Categories:

Process(es)

blood vessel development
patterning of blood vessels
vasculogenesis
in utero embryonic development
heart looping
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
outflow tract morphogenesis
growth plate cartilage chondrocyte growth
protein phosphorylation
receptor-mediated endocytosis
apoptotic process
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
Notch signaling pathway
smoothened signaling pathway
gastrulation
brain development
heart development
embryo implantation
aging
response to nutrient
positive regulation of cell proliferation
response to mechanical stimulus
response to glucose
regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
activation of protein kinase activity
embryonic hemopoiesis
wound healing
regulation of cell proliferation
response to drug
myeloid dendritic cell differentiation
positive regulation of skeletal muscle tissue regeneration
response to estrogen
positive regulation of angiogenesis
response to steroid hormone
digestive tract development
positive regulation of smooth muscle cell proliferation
embryonic cranial skeleton morphogenesis
positive regulation of NK T cell differentiation
palate development
negative regulation of cardiac muscle cell proliferation
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
bronchus morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
response to cholesterol
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
lens fiber cell apoptotic process
positive regulation of reactive oxygen species metabolic process

Function(s)

transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
mitogen-activated protein kinase kinase kinase binding
type I transforming growth factor beta receptor binding
SMAD binding
metal ion binding
transforming growth factor beta binding