4035

• Gene Symbol: BMP4
• Gene Name: bone morphogenetic protein 4
• Gene Aliases: BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
• Chromosome Location: Chr.14: 53949736 - 53956862 on Build GRCh38
• UniGene ID: Hs.68879
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: BMP4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001202.4	NP_001193.2	4	1211
	NM_130850.3	NP_570911.2	4	1002
	XM_005268015.4	XP_005268072.1	4	2415
	XM_017021603.1	XP_016877092.1	4	991
	XM_017021604.1	XP_016877093.1	4	1118
	XM_017021605.1	XP_016877094.1	4	1265
GenBank mRNA	BC020546.2	-	4	967	4399276
	BX161385.1	-	3	953
	BX161438.1	-	4	958
	D30751.1	-	2	849
	KM220602.1	-	3	874
	M22490.1	-	4	1160

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012827, XM_006251748, XM_006251746, XM_006251749, XM_008770501, and others.

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPKK activity
ovarian follicle development
osteoblast differentiation
ureteric bud development
branching involved in ureteric bud morphogenesis
kidney development
mesonephros development
neural tube closure
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
endochondral ossification
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
chondrocyte differentiation
hematopoietic progenitor cell differentiation
lymphoid progenitor cell differentiation
renal system process
BMP signaling pathway involved in heart induction
secondary heart field specification
outflow tract septum morphogenesis
membranous septum morphogenesis
muscular septum morphogenesis
aortic valve morphogenesis
pulmonary valve morphogenesis
endocardial cushion development
epithelial to mesenchymal transition involved in endocardial cushion formation
cardiac right ventricle morphogenesis
apoptotic process involved in endocardial cushion morphogenesis
cardiac septum development
type B pancreatic cell development
mesenchymal to epithelial transition involved in metanephros morphogenesis
common-partner SMAD protein phosphorylation
smoothened signaling pathway
germ cell development
mesodermal cell fate determination
negative regulation of cell proliferation
post-embryonic development
anterior/posterior axis specification
specification of organ position
regulation of cell fate commitment
positive regulation of calcium ion transport into cytosol
positive regulation of endothelial cell migration
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of cell death
positive regulation of neuron projection development
telencephalon development
dorsal/ventral neural tube patterning
telencephalon regionalization
pituitary gland development
erythrocyte differentiation
monocyte differentiation
macrophage differentiation
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of protein binding
negative regulation of chondrocyte differentiation
response to estradiol
response to retinoic acid
positive regulation of collagen biosynthetic process
negative regulation of T cell differentiation in thymus
negative regulation of immature T cell proliferation in thymus
response to testosterone
protein localization to nucleus
cellular response to oxidative stress
embryonic hindlimb morphogenesis
tendon cell differentiation
deltoid tuberosity development
wound healing
regulation of protein import into nucleus
negative regulation of phosphorylation
odontogenesis of dentin-containing tooth
odontogenesis
regulation of odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
positive regulation of apoptotic process
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
negative regulation of MAP kinase activity
tongue morphogenesis
positive regulation of endothelial cell differentiation
positive regulation of epidermal cell differentiation
negative regulation of myoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of cell cycle
negative regulation of mitotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
intermediate mesodermal cell differentiation
positive regulation of smooth muscle cell proliferation
neuron fate commitment
embryonic cranial skeleton morphogenesis
negative regulation of oligodendrocyte differentiation
smooth muscle tissue development
branching morphogenesis of an epithelial tube
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
positive chemotaxis
regulation of smooth muscle cell differentiation
response to glucocorticoid
positive regulation of cardiac muscle fiber development
anatomical structure regression
retina development in camera-type eye
inner ear receptor cell differentiation
cloacal septation
lens induction in camera-type eye
embryonic skeletal joint morphogenesis
cranial suture morphogenesis
positive regulation of SMAD protein import into nucleus
regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
lung morphogenesis
bronchus development
trachea development
trachea formation
epithelial tube branching involved in lung morphogenesis
branching involved in prostate gland morphogenesis
bud elongation involved in lung branching
lung lobe development
epithelial cell proliferation involved in lung morphogenesis
bud dilation involved in lung branching
negative regulation of cell death
mammary gland formation
epithelial-mesenchymal cell signaling
negative regulation of prostatic bud formation
regulation of branching involved in prostate gland morphogenesis
coronary vasculature development
positive regulation of cartilage development
positive regulation of branching involved in lung morphogenesis
BMP signaling pathway involved in ureter morphogenesis
BMP signaling pathway involved in renal system segmentation
pulmonary artery endothelial tube morphogenesis
BMP signaling pathway involved in heart development
pharyngeal arch artery morphogenesis
negative regulation of thymocyte apoptotic process
positive regulation of hepatocyte differentiation
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
response to nitric oxide
cellular response to BMP stimulus
BMP signaling pathway involved in nephric duct formation
renal system development
glomerular visceral epithelial cell development
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
glomerular capillary formation
negative regulation of glomerular mesangial cell proliferation
mesenchymal cell proliferation involved in ureteric bud development
mesenchymal cell differentiation involved in kidney development
ureter epithelial cell differentiation
ureter smooth muscle cell differentiation
mesenchymal cell proliferation involved in ureter development
negative regulation of mesenchymal cell proliferation involved in ureter development
metanephric collecting duct development
positive regulation of kidney development
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of glomerulus development
cellular response to thyroid hormone stimulus
positive regulation of store-operated calcium channel activity
positive regulation of cell proliferation involved in outflow tract morphogenesis
positive regulation of mesenchymal stem cell proliferation
cardiac jelly development
negative regulation of metanephric S-shaped body morphogenesis
negative regulation of metanephric comma-shaped body morphogenesis
positive regulation of DNA-dependent DNA replication
negative regulation of cell proliferation involved in heart morphogenesis
positive regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

cytokine activity
transforming growth factor beta receptor binding
protein binding
growth factor activity
heparin binding
co-receptor binding
chemoattractant activity
protein homodimerization activity
BMP receptor binding