41775

• Gene Symbol: APOE
• Gene Name: apolipoprotein E
• Gene Aliases: AD2, APO-E, LDLCQ5, LPG
• Chromosome Location: Chr.19: 44905749 - 44909395 on Build GRCh38
• UniGene ID: Hs.654439
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: APOE
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000041.3	NP_000032.1	4	1202
	NM_001302688.1	NP_001289617.1	4	1284
	NM_001302689.1	NP_001289618.1	4	1133
	NM_001302690.1	NP_001289619.1	4	1233
	NM_001302691.1	NP_001289620.1	4	1217
GenBank mRNA	AL037046.3	-	1	358
	BC003557.1	-	4	1131	3355712
	K00396.1	-	4	1146
	M12529.1	-	4	1147

More Information

Panther Classification:

Molecular Function -

apolipoprotein

Gene Ontology Categories:

Process(es)

response to reactive oxygen species
retinoid metabolic process
negative regulation of endothelial cell proliferation
response to dietary excess
triglyceride metabolic process
cholesterol catabolic process
cellular calcium ion homeostasis
receptor-mediated endocytosis
cytoskeleton organization
G-protein coupled receptor signaling pathway
nitric oxide mediated signal transduction
synaptic transmission, cholinergic
cholesterol metabolic process
regulation of gene expression
negative regulation of platelet activation
positive regulation of cholesterol esterification
positive regulation of cholesterol efflux
long-chain fatty acid transport
protein import
virion assembly
triglyceride catabolic process
cGMP-mediated signaling
negative regulation of blood coagulation
regulation of axon extension
positive regulation of cGMP biosynthetic process
neuron projection regeneration
regulation of Cdc42 protein signal transduction
positive regulation of low-density lipoprotein particle receptor catabolic process
cholesterol efflux
phospholipid efflux
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
chylomicron remnant clearance
high-density lipoprotein particle clearance
very-low-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein biosynthetic process
lipoprotein catabolic process
vasodilation
cholesterol homeostasis
negative regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of blood vessel endothelial cell migration
reverse cholesterol transport
positive regulation by host of viral process
negative regulation of cholesterol biosynthetic process
positive regulation of lipid biosynthetic process
intracellular transport
regulation of neuronal synaptic plasticity
artery morphogenesis
negative regulation of inflammatory response
positive regulation of nitric-oxide synthase activity
positive regulation of membrane protein ectodomain proteolysis
maintenance of location in cell
fatty acid homeostasis
positive regulation of dendritic spine development
negative regulation of canonical Wnt signaling pathway
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
cellular oxidant detoxification
regulation of beta-amyloid clearance
negative regulation of neuron death
positive regulation of postsynaptic membrane organization
negative regulation of presynaptic membrane organization
negative regulation of beta-amyloid formation
positive regulation of dendritic spine maintenance
positive regulation of phospholipid efflux
positive regulation of lipid transport across blood brain barrier

Function(s)

beta-amyloid binding
lipid transporter activity
protein binding
phospholipid binding
heparin binding
lipid binding
cholesterol binding
antioxidant activity
cholesterol transporter activity
identical protein binding
protein homodimerization activity
metal chelating activity
tau protein binding
low-density lipoprotein particle receptor binding
phosphatidylcholine-sterol O-acyltransferase activator activity
very-low-density lipoprotein particle receptor binding
lipoprotein particle binding