42843

• Gene Symbol: LEF1
• Gene Name: lymphoid enhancer binding factor 1
• Gene Aliases: LEF-1, TCF10, TCF1ALPHA, TCF7L3
• Chromosome Location: Chr.4: 108047545 - 108168956 on Build GRCh38
• UniGene ID: Hs.743478
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LEF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001130713.2	NP_001124185.1	1	1299
	NM_001130714.2	NP_001124186.1	1	1299
	NM_016269.4	NP_057353.1	1	1299
	XM_005263046.3	XP_005263103.1	1	303
GenBank mRNA	AF198532.1	-	1	110
	AF288571.1	-	1	764
	AF294627.1	-	1	110
	AK225772.1	-	1	1187
	AK294395.1	-	1	141
	BC040559.1	-	1	132	5269696
	BC050632.2	-	1	201	6054813

More Information

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
osteoblast differentiation
neural crest cell migration
somitogenesis
kidney development
epithelial to mesenchymal transition
sprouting angiogenesis
transcription from RNA polymerase II promoter
Wnt signaling pathway, calcium modulating pathway
positive regulation of cell proliferation
response to lithium ion
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
regulation of striated muscle tissue development
dentate gyrus development
hypothalamus development
forebrain radial glial cell differentiation
forebrain neuroblast division
forebrain neuron differentiation
formation of radial glial scaffolds
regulation of cell-cell adhesion
neutrophil differentiation
positive regulation of cell growth
embryonic limb morphogenesis
positive regulation of cell migration
BMP signaling pathway
positive regulation of granulocyte differentiation
mammary gland development
organ regeneration
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
T cell receptor V(D)J recombination
B cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA binding
steroid hormone mediated signaling pathway
tongue development
skin development
positive regulation by host of viral transcription
histone H3 acetylation
histone H4 acetylation
T-helper 1 cell differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
alpha-beta T cell differentiation
eye pigmentation
paraxial mesoderm formation
muscle fiber development
sensory perception of taste
palate development
anatomical structure regression
canonical Wnt signaling pathway
face morphogenesis
cell chemotaxis
apoptotic process involved in morphogenesis
chorio-allantoic fusion
trachea gland development
cellular response to cytokine stimulus
cellular response to interleukin-4
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
odontoblast differentiation
negative regulation of estrogen receptor binding
negative regulation of canonical Wnt signaling pathway
apoptotic process involved in patterning of blood vessels
beta-catenin-TCF complex assembly

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
beta-catenin binding
transcription factor binding
DNA binding, bending
estrogen receptor activity
estrogen receptor binding
enhancer binding
histone binding
histone deacetylase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding