4285 Validated

• Gene Symbol: F2R
• Gene Name: coagulation factor II thrombin receptor
• Gene Aliases: CF2R, HTR, PAR-1, PAR1, TR
• Chromosome Location: Chr.5: 76716043 - 76735780 on Build GRCh38
• UniGene ID: Hs.482562
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: F2R
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001311313.1	NP_001298242.1	3	566
	NM_001992.4	NP_001983.2	2	444
GenBank mRNA	AK308169.1	-	2	444
	AK314202.1	-	2	367
	BC002464.2	-	2	359	3343051
	BC051909.1	-	2	365	6172703
	BT007279.1	-	2	179
	DA799420.1	-	3	474
	M62424.1	-	2	403

More Information

Matching Taqman Gene Expression Assay:

Hs00169258_m1

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
connective tissue replacement involved in inflammatory response wound healing
negative regulation of glomerular filtration
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
establishment of synaptic specificity at neuromuscular junction
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
anatomical structure morphogenesis
positive regulation of phosphatidylinositol 3-kinase signaling
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell migration
response to lipopolysaccharide
regulation of interleukin-1 beta production
positive regulation of collagen biosynthetic process
positive regulation of Rho protein signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of JAK-STAT cascade
homeostasis of number of cells within a tissue
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of calcium ion transport
regulation of sensory perception of pain
platelet dense granule organization
positive regulation of ERK1 and ERK2 cascade
thrombin receptor signaling pathway
negative regulation of renin secretion into blood stream
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion

Function(s)

G-protein alpha-subunit binding
G-protein coupled receptor activity
receptor binding
protein binding
thrombin receptor activity
G-protein beta-subunit binding