4399

• Gene Symbol: JUN
• Gene Name: Jun proto-oncogene, AP-1 transcription factor subunit
• Gene Aliases: AP-1, AP1, c-Jun
• Chromosome Location: Chr.1: 58780791 - 58784113 on Build GRCh38
• UniGene ID: Hs.696684
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: JUN
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002228.3	NP_002219.1	1	3191

More Information

Panther Classification:

Molecular Function -

basic leucine zipper transcription factor

Gene Ontology Categories:

Process(es)

angiogenesis
microglial cell activation
release of cytochrome c from mitochondria
liver development
positive regulation of endothelial cell proliferation
outflow tract morphogenesis
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
Ras protein signal transduction
aging
learning
circadian rhythm
negative regulation of cell proliferation
response to radiation
response to mechanical stimulus
positive regulation of epithelial cell migration
regulation of cell death
monocyte differentiation
axon regeneration
negative regulation of protein autophosphorylation
response to lipopolysaccharide
cellular response to hormone stimulus
response to cytokine
leading edge cell differentiation
response to muscle stretch
Fc-epsilon receptor signaling pathway
regulation of cell proliferation
response to drug
response to hydrogen peroxide
negative regulation of DNA binding
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation by host of viral transcription
positive regulation by host of viral transcription
positive regulation of cell differentiation
positive regulation of monocyte differentiation
positive regulation of DNA replication
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
cellular response to potassium ion starvation
response to cAMP
regulation of cell cycle
membrane depolarization
SMAD protein signal transduction
eyelid development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of DNA-templated transcription, initiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
GTPase activator activity
protein binding
transcription factor binding
enzyme binding
cAMP response element binding
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
poly(A) RNA binding
protein heterodimerization activity
R-SMAD binding
HMG box domain binding