44232

• Gene Symbol: PYCARD
• Gene Name: PYD and CARD domain containing
• Gene Aliases: ASC, CARD5, TMS, TMS-1, TMS1
• Chromosome Location: Chr.16: 31201486 - 31202776 on Build GRCh38
• UniGene ID: Hs.499094
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PYCARD
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013258.4	NP_037390.2	3	564
	NM_145182.2	NP_660183.1	2	507
GenBank mRNA	AB023416.2	-	3	564
	AF184073.1	-	3	552
	AF255794.1	-	2	495
	AF310103.1	-	3	478
	AF384665.1	-	3	531
	AK000211.1	-	3	516
	AK314422.1	-	3	556
	BC004470.2	-	4	534	3678925
	BC013569.1	-	3	471

More Information

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

myeloid dendritic cell activation
activation of innate immune response
myeloid dendritic cell activation involved in immune response
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
positive regulation of adaptive immune response
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
signal transduction
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of actin filament polymerization
regulation of protein stability
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
tumor necrosis factor-mediated signaling pathway
positive regulation of activated T cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
macropinocytosis
innate immune response
positive regulation of JNK cascade
positive regulation of interleukin-1 beta secretion
positive regulation of phagocytosis
defense response to Gram-negative bacterium
positive regulation of T cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
defense response to virus
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
negative regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of chemokine secretion
positive regulation of release of cytochrome c from mitochondria
positive regulation of T cell migration
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
positive regulation of cysteine-type endopeptidase activity
positive regulation of interleukin-10 secretion
positive regulation of extrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway

Function(s)

protease binding
interleukin-6 receptor binding
protein binding
tropomyosin binding
cysteine-type endopeptidase activator activity involved in apoptotic process
myosin I binding
enzyme binding
Pyrin domain binding
identical protein binding
protein homodimerization activity
BMP receptor binding
cysteine-type endopeptidase activity involved in apoptotic process