4495

• Gene Symbol: SPI1
• Gene Name: Spi-1 proto-oncogene
• Gene Aliases: OF, PU.1, SFPI1, SPI-1, SPI-A
• Chromosome Location: Chr.11: 47354858 - 47395640 on Build GRCh38
• UniGene ID: Hs.502511
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SPI1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001080547.1	NP_001074016.1	4, 5	727
	NM_003120.2	NP_003111.2	4, 5	724
	XM_011520307.1	XP_011518609.1	6, 7	2169
	XM_017018173.1	XP_016873662.1	6, 7	2172
GenBank mRNA	BI909430.1	-	4, 5	528
	X52056.1	-	4, 5	694

More Information

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
lymphoid progenitor cell differentiation
transcription from RNA polymerase II promoter
lymphocyte differentiation
erythrocyte differentiation
macrophage differentiation
granulocyte differentiation
somatic stem cell population maintenance
myeloid dendritic cell differentiation
histone H3 acetylation
hypermethylation of CpG island
negative regulation of MHC class II biosynthetic process
regulation of erythrocyte differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure regression
cellular response to ethanol
negative regulation of histone H4 acetylation
apoptotic process involved in patterning of blood vessels
positive regulation of pri-miRNA transcription from RNA polymerase II promoter

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
RNA binding
protein binding
NFAT protein binding