453

• Gene Symbol: RIPK1
• Gene Name: receptor interacting serine/threonine kinase 1
• Gene Aliases: RIP, RIP-1, RIP1
• Chromosome Location: Chr.6: 3063888 - 3115187 on Build GRCh38
• UniGene ID: Hs.519842
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RIPK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001317061.1	NP_001303990.1	4	593
	NM_003804.4	NP_003795.2	3	429
	XM_005249457.3	XP_005249514.2	3	352
	XM_006715237.3	XP_006715300.2	3	352
	XM_017011405.1	XP_016866894.1	3	350
GenBank mRNA	AB208926.1	-	4	502
	AK304701.1	-	2	156
	AK314176.1	-	3	429
	BC126254.1	-	2	223	8991970
	BC126256.1	-	2	223	8991972
	U50062.1	-	2	197

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
I-kappaB kinase/NF-kappaB signaling
activation of JUN kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
positive regulation of necrotic cell death
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
tumor necrosis factor-mediated signaling pathway
response to tumor necrosis factor
TRIF-dependent toll-like receptor signaling pathway
peptidyl-serine autophosphorylation
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular protein catabolic process
positive regulation of macrophage differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
protein heterooligomerization
positive regulation of necroptotic process
T cell apoptotic process
necroptotic process
regulation of ATP:ADP antiporter activity
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
death-inducing signaling complex assembly
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ripoptosome assembly
necroptotic signaling pathway
ripoptosome assembly involved in necroptotic process
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of hydrogen peroxide-induced cell death
amyloid fibril formation
positive regulation of reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

protein kinase activity
protein serine/threonine kinase activity
death receptor binding
protein binding
ATP binding
ubiquitin protein ligase binding
protein complex binding
identical protein binding
death domain binding