45428

• Gene Symbol: SIRT6
• Gene Name: sirtuin 6
• Gene Aliases: SIR2L6
• Chromosome Location: Chr.19: 4174109 - 4182604 on Build GRCh38
• UniGene ID: Hs.423756
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SIRT6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001193285.2	NP_001180214.1	3	316
	NM_001321058.1	NP_001307987.1	2	188
	NM_001321060.1	NP_001307989.1	3	316
	NM_001321061.1	NP_001307990.1	2	188
	NM_001321064.1	NP_001307993.1	3	281
	NM_016539.3	NP_057623.2	3	316
GenBank mRNA	AF233396.1	-	3	311
	AK074810.1	-	3	279
	AK225567.1	-	3	284
	AK293348.1	-	2	149
	AK299420.1	-	2	131
	AK315048.1	-	3	280
	AL365375.1	-		732
	AL559383.3	-	3	254
	BC004218.2	-	2	128	3352203
	BC005026.1	-	3	254	2820472
	BC028220.1	-	3	262	5217599
	CN364175.1	-	3	259
	CN364177.1	-	3	319
	CR457200.1	-	3	251

More Information

Gene Ontology Categories:

Process(es)

post-embryonic cardiac muscle cell growth involved in heart morphogenesis
base-excision repair
protein ADP-ribosylation
negative regulation of cell proliferation
regulation of double-strand break repair via homologous recombination
protein destabilization
response to nutrient levels
glucose homeostasis
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of glucose import
positive regulation of fibroblast proliferation
histone H3-K9 modification
histone H3-K9 deacetylation
positive regulation of stem cell proliferation

Function(s)

chromatin binding
transcription corepressor activity
NAD+ ADP-ribosyltransferase activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD+ binding