455

• Gene Symbol: RIPK2
• Gene Name: receptor interacting serine/threonine kinase 2
• Gene Aliases: CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
• Chromosome Location: Chr.8: 89757747 - 89791064 on Build GRCh38
• UniGene ID: Hs.103755
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RIPK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003821.5	NP_003812.1	4	881
	XM_005251092.3	XP_005251149.1	3	691
	XM_011517357.2	XP_011515659.1	2	214
GenBank mRNA	AF027706.1	-	4	791
	AF064824.1	-	4	809
	AF078530.1	-	4	567
	AK075213.1	-	4	785
	AK301448.1	-	3	640
	AY358813.1	-	3	638
	AY358814.1	-	4	818
	AY524045.1	-	4	654
	BC004553.2	-	4	769	4026156
	KU178437.1	-	4	567
	KU178438.1	-	3	413

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

activation of MAPK activity
positive regulation of cytokine-mediated signaling pathway
adaptive immune response
apoptotic process
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
JNK cascade
positive regulation of peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of immature T cell proliferation
positive regulation of peptidyl-serine phosphorylation
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
T cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
innate immune response
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to interleukin-1
response to interleukin-12
response to interleukin-18
cellular response to lipoteichoic acid
cellular response to peptidoglycan
cellular response to muramyl dipeptide
positive regulation of xenophagy

Function(s)

protein serine/threonine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
receptor binding
protein binding
ATP binding
LIM domain binding
protein homodimerization activity
CARD domain binding