465

• Gene Symbol: RPS6KA4
• Gene Name: ribosomal protein S6 kinase A4
• Gene Aliases: MSK2, RSK-B, S6K-alpha-4
• Chromosome Location: Chr.11: 64359153 - 64372215 on Build GRCh38
• UniGene ID: Hs.105584
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RPS6KA4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001006944.1	NP_001006945.1	2	172
	NM_001300802.1	NP_001287731.1	2	172
	NM_003942.2	NP_003933.1	2	172
	XM_005274380.1	XP_005274437.1	2	152
GenBank mRNA	AF074715.1	-	1	41
	AJ010119.1	-	2	154
	AK223561.1	-	2	177
	AK292163.1	-	2	153
	AK313567.1	-	2	152
	BC028079.1	-	2	136
	BC047896.1	-	2	151	5763859
	BI253655.1	-	2	172
	BI523588.1	-	2	197

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108517, BU671341, DN932052.
This siRNA also targets the following transcripts in Mouse: NM_019924, AK154674, AF074714, BC012964, AK089467, and others.

Panther Classification:

Molecular Function -

protein modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of cytokine production
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
histone phosphorylation
positive regulation of CREB transcription factor activity
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
histone H3-S10 phosphorylation
histone H3-S28 phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway

Function(s)

magnesium ion binding
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein binding
ATP binding
histone kinase activity (H3-S10 specific)
mitogen-activated protein kinase p38 binding