4671

• Gene Symbol: SFRP1
• Gene Name: secreted frizzled related protein 1
• Gene Aliases: FRP, FRP-1, FRP1, FrzA, SARP2
• Chromosome Location: Chr.8: 41261957 - 41309471 on Build GRCh38
• UniGene ID: Hs.213424
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SFRP1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003012.4	NP_003003.3	3	1196
GenBank mRNA	AF001900.1	-	3	1183
	AF017987.1	-	3	1186
	AF056087.1	-	3	1183
	AK127331.1	-	3	609
	AK293090.1	-	4	1009
	BC036503.1	-	3	1203	5265277

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001276712.
This siRNA also targets the following transcripts in Mouse: NM_013834, U88566, AK088868, AK081052, BC094662, and others.

• Set Membership: G-protein coupled receptor

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

osteoblast differentiation
ureteric bud development
positive regulation of cell-matrix adhesion
hematopoietic progenitor cell differentiation
proteolysis
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
female gonad development
cellular response to starvation
dorsal/ventral axis specification
regulation of cell cycle process
negative regulation of gene expression
negative regulation of epithelial to mesenchymal transition
neural crest cell fate commitment
response to organic cyclic compound
menstrual cycle phase
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
negative regulation of ossification
positive regulation of cell growth
negative regulation of cell growth
negative regulation of cell migration
negative regulation of BMP signaling pathway
negative regulation of osteoblast proliferation
somatic stem cell population maintenance
response to drug
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of JUN kinase activity
positive regulation of GTPase activity
cellular response to fibroblast growth factor stimulus
stromal-epithelial cell signaling involved in prostate gland development
negative regulation of B cell differentiation
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
negative regulation of osteoclast differentiation
regulation of angiogenesis
positive regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of insulin secretion
negative regulation of bone remodeling
negative regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
canonical Wnt signaling pathway
hematopoietic stem cell differentiation
bone trabecula formation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
regulation of branching involved in prostate gland morphogenesis
negative regulation of androgen receptor signaling pathway
cellular response to vitamin D
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
cellular response to prostaglandin E stimulus
cellular response to estrogen stimulus
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to X-ray
cellular response to heparin
dopaminergic neuron differentiation
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
negative regulation of canonical Wnt signaling pathway
planar cell polarity pathway involved in neural tube closure
Wnt signaling pathway involved in somitogenesis
convergent extension involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of dopaminergic neuron differentiation
midbrain morphogenesis
negative regulation of planar cell polarity pathway involved in axis elongation
positive regulation of non-canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
negative regulation of fibroblast apoptotic process
positive regulation of fibroblast apoptotic process

Function(s)

cysteine-type endopeptidase activity
G-protein coupled receptor activity
frizzled binding
protein binding
drug binding
heparin binding
Wnt-protein binding
identical protein binding
Wnt-activated receptor activity