46729

• Gene Symbol: App
• Gene Name: amyloid beta (A4) precursor protein
• Gene Aliases: Abeta
• Chromosome Location: Chr.11: 24425013 - 24641837 on Build Rnor_6.0
• UniGene ID: Rn.2104
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: App
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_019288.2	NP_062161.1	2	204
	XM_006248008.2	XP_006248070.1	2	334
	XM_006248009.2	XP_006248071.1	2	334
	XM_006248010.2	XP_006248072.1	2	334
	XM_006248011.2	XP_006248073.1	2	334
	XM_006248012.2	XP_006248074.1	2	334
GenBank mRNA	AF513015.1	-	2	205
	BC062082.1	-	2	317	5599880
	FQ221425.1	-	2	337

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001204303, NM_001204302, NM_001136131, NM_201413, NM_201414, and others.
This siRNA also targets the following transcripts in Mouse: NM_001198826, NM_001198824, NM_001198823, NM_001198825, NM_007471, and others.

Panther Classification:

Molecular Function -

protease inhibitor

Gene Ontology Categories:

Process(es)

suckling behavior
mRNA polyadenylation
regulation of translation
protein phosphorylation
cellular copper ion homeostasis
endocytosis
response to oxidative stress
cell adhesion
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
axonogenesis
mating behavior
locomotory behavior
axo-dendritic transport
cholesterol metabolic process
adult locomotory behavior
visual learning
regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of peptidase activity
positive regulation of G2/M transition of mitotic cell cycle
axon midline choice point recognition
neuron remodeling
dendrite development
extracellular matrix organization
forebrain development
neuron projection development
ionotropic glutamate receptor signaling pathway
regulation of multicellular organism growth
regulation of protein binding
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting in absence of injury
regulation of synapse structure or activity
neuromuscular process controlling balance
synaptic growth at neuromuscular junction
neuron apoptotic process
smooth endoplasmic reticulum calcium ion homeostasis

Function(s)

DNA binding
serine-type endopeptidase inhibitor activity
receptor binding
protein binding
heparin binding
peptidase activator activity
enzyme binding
acetylcholine receptor binding
identical protein binding
transition metal ion binding
PTB domain binding
growth factor receptor binding