48797

• Gene Symbol: Pax6
• Gene Name: paired box 6
• Gene Aliases: -
• Chromosome Location: Chr.3: 95699478 - 95728556 on Build Rnor_6.0
• UniGene ID: Rn.89724
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pax6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013001.2	NP_037133.1	5	344
	XM_006234633.2	XP_006234695.1	7	769
	XM_006234634.2	XP_006234696.1	7	2225
	XM_006234635.2	XP_006234697.1	7	684
	XM_006234636.2	XP_006234698.1	7	1675
	XM_008762060.1	XP_008760282.1	6	868
GenBank mRNA	AJ627631.1	-	3	226
	AY540905.1	-	4	241
	AY540906.1	-	4	241
	BC128741.1	-	5	344	8363963
	HQ121510.1	-	3	227
	U69644.1	-	5	564

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001258463, NM_001604, NM_000280, NM_001258465, NM_001127612, and others.
This siRNA also targets the following transcripts in Mouse: NM_001244200, NM_001244198, NM_013627, NM_001244201, NM_001244202, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
blood vessel development
cell fate determination
neural crest cell migration
neuron migration
negative regulation of protein phosphorylation
positive regulation of neuroblast proliferation
epithelial cell development
lens development in camera-type eye
type B pancreatic cell differentiation
pancreatic A cell differentiation
pancreatic A cell development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
axonogenesis
axon guidance
central nervous system development
brain development
salivary gland morphogenesis
negative regulation of cell proliferation
response to wounding
regulation of asymmetric cell division
dorsal/ventral axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
positive regulation of gene expression
regulation of neuron projection development
protein ubiquitination
spinal cord development
pallium development
cerebellum development
rhombomere morphogenesis
olfactory bulb development
oligodendrocyte cell fate specification
cerebral cortex regionalization
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
commitment of neuronal cell to specific neuron type in forebrain
forebrain-midbrain boundary formation
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
telencephalon regionalization
pituitary gland development
interkinetic nuclear migration
signal transduction involved in regulation of gene expression
cell differentiation
keratinocyte differentiation
regulation of cell migration
positive regulation of epithelial cell differentiation
forebrain development
hindbrain development
lacrimal gland development
cellular response to insulin stimulus
protein localization to organelle
cellular response to drug
eye photoreceptor cell development
glucose homeostasis
positive regulation of cell fate specification
camera-type eye development
cellular response to fibroblast growth factor stimulus
cell fate commitment
response to ethanol
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
embryonic camera-type eye morphogenesis
astrocyte differentiation
negative regulation of epithelial cell proliferation
regulation of neurogenesis
negative regulation of neurogenesis
retina development in camera-type eye
iris morphogenesis
cornea development in camera-type eye
neural precursor cell proliferation
positive regulation of glucagon secretion
cellular response to glucose stimulus
cellular response to prostaglandin E stimulus
insulin metabolic process
negative regulation of neural precursor cell proliferation
positive regulation of neuron migration

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
AT DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
transcription factor binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
co-SMAD binding
R-SMAD binding
HMG box domain binding