49034

• Gene Symbol: Lep
• Gene Name: leptin
• Gene Aliases: OB, obese
• Chromosome Location: Chr.4: 56337695 - 56351818 on Build Rnor_6.0
• UniGene ID: Rn.44444
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Lep
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013076.3	NP_037208.1	1	140
	XM_008762762.1	XP_008760984.1	1	228
GenBank mRNA	D45862.1	-	2	152
	D49653.1	-	1	121
	S78586.1	-	1	92
	U48849.1	-	1	53

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_008493, HQ166716, FJ374142, AK030984, BC125245, and others.

Panther Classification:

Molecular Function -

peptide hormone

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
response to hypoxia
positive regulation of cytokine production
placenta development
regulation of protein phosphorylation
response to dietary excess
cardiac muscle hypertrophy
glucose metabolic process
regulation of gluconeogenesis
energy reserve metabolic process
glycerol biosynthetic process
lipid metabolic process
fatty acid beta-oxidation
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
female pregnancy
response to nutrient
circadian rhythm
cholesterol metabolic process
bile acid metabolic process
regulation of blood pressure
positive regulation of cell proliferation
adult feeding behavior
fatty acid catabolic process
negative regulation of metabolic process
regulation of metabolic process
cAMP-mediated signaling
central nervous system neuron development
insulin secretion
regulation of intestinal cholesterol absorption
negative regulation of appetite
response to insulin
response to vitamin E
leptin-mediated signaling pathway
positive regulation of luteinizing hormone secretion
positive regulation of peroxisome proliferator activated receptor signaling pathway
intracellular signal transduction
bone mineralization involved in bone maturation
positive regulation of protein import into nucleus
hormone metabolic process
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
positive regulation of ion transport
positive regulation of MAPK cascade
regulation of fat cell differentiation
positive regulation of myeloid cell differentiation
negative regulation of vasoconstriction
positive regulation of JAK-STAT cascade
positive regulation of insulin receptor signaling pathway
positive regulation of follicle-stimulating hormone secretion
positive regulation of developmental growth
regulation of insulin secretion
regulation of steroid biosynthetic process
leukocyte tethering or rolling
regulation of lipoprotein lipid oxidation
adipose tissue development
negative regulation of cartilage development
negative regulation of glucagon secretion
cellular response to L-ascorbic acid
cellular response to retinoic acid
regulation of protein localization to nucleus
positive regulation of STAT protein import into nucleus
positive regulation of reactive oxygen species metabolic process
negative regulation of glutamine transport
positive regulation of hepatic stellate cell activation

Function(s)

cytokine activity
hormone activity
growth factor activity
peptide hormone receptor binding