50347

• Gene Symbol: Ptk2b
• Gene Name: protein tyrosine kinase 2 beta
• Gene Aliases: CAKB, CAKbeta, Pyk2
• Chromosome Location: Chr.15: 42827306 - 42947785 on Build Rnor_6.0
• UniGene ID: Rn.11025
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptk2b
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_017318.2	NP_059014.2	3	436
	XM_006252143.2	XP_006252205.1	3	761
	XM_006252144.2	XP_006252206.1	3	3752
	XM_006252145.2	XP_006252207.1	3	565
	XM_008770773.1	XP_008768995.1	3	1949
	XM_008770774.1	XP_008768996.1	3	1515
GenBank mRNA	BC101921.1	-	3	436	7937929
	D45854.1	-	3	614
	U69109.1	-	2	356

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_172498, NM_001162366, NM_001162365, AK054002, BC137704, and others.

Gene Ontology Categories:

Process(es)

MAPK cascade
response to reactive oxygen species
angiogenesis
oocyte maturation
response to hypoxia
positive regulation of cell-matrix adhesion
sprouting angiogenesis
marginal zone B cell differentiation
protein phosphorylation
cellular defense response
response to osmotic stress
actin filament organization
cell adhesion
cell surface receptor signaling pathway
signal complex assembly
epidermal growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to mechanical stimulus
response to hormone
response to glucose
response to lithium ion
response to organonitrogen compound
positive regulation of endothelial cell migration
negative regulation of muscle cell apoptotic process
regulation of cGMP-mediated signaling
regulation of macrophage chemotaxis
positive regulation of neuron projection development
glial cell proliferation
peptidyl-tyrosine phosphorylation
cell differentiation
regulation of cell adhesion
negative regulation of ossification
positive regulation of cell growth
positive regulation of cell migration
negative regulation of bone mineralization
regulation of cGMP biosynthetic process
positive regulation of actin filament polymerization
neuron projection development
regulation of inositol trisphosphate biosynthetic process
tumor necrosis factor-mediated signaling pathway
ionotropic glutamate receptor signaling pathway
response to immobilization stress
peptidyl-tyrosine autophosphorylation
response to cocaine
response to drug
response to hydrogen peroxide
activation of Janus kinase activity
negative regulation of apoptotic process
stress fiber assembly
negative regulation of potassium ion transport
positive regulation of JUN kinase activity
negative regulation of neuron apoptotic process
blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of nitric oxide biosynthetic process
bone resorption
response to ethanol
negative regulation of myeloid cell differentiation
positive regulation of translation
positive regulation of angiogenesis
positive regulation of protein kinase activity
positive regulation of JNK cascade
vascular endothelial growth factor receptor signaling pathway
focal adhesion assembly
positive regulation of peptidyl-tyrosine phosphorylation
regulation of calcium-mediated signaling
positive regulation of nitric-oxide synthase activity
regulation of release of sequestered calcium ion into cytosol
response to cAMP
response to calcium ion
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
cellular response to fluid shear stress
activation of GTPase activity
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of establishment of cell polarity
regulation of actin cytoskeleton reorganization
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of reactive oxygen species metabolic process
positive regulation of excitatory postsynaptic potential
positive regulation of B cell chemotaxis

Function(s)

protein kinase activity
calmodulin-dependent protein kinase activity
non-membrane spanning protein tyrosine kinase activity
NMDA glutamate receptor activity
receptor binding
protein binding
ATP binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding