50457

• Gene Symbol: Isl1
• Gene Name: ISL LIM homeobox 1
• Gene Aliases: Isl-1, isl-1=homeobox
• Chromosome Location: Chr.2: 48488911 - 48501217 on Build Rnor_6.0
• UniGene ID: Rn.36202
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Isl1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_017339.3	NP_059035.3	2, 3	231
GenBank mRNA	AY557632.1	-	2, 3	226
	S69329.1	-	2, 3	231
	X53258.1	-	2, 3	334

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_002202, U07559, BC031213, S70721, AK290742.
This siRNA also targets the following transcripts in Mouse: NM_021459, CF725499, BC132263, BC132609, AJ132765, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
heart morphogenesis
secondary heart field specification
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
regulation of secondary heart field cardioblast proliferation
regulation of transcription, DNA-templated
heart development
positive regulation of cell proliferation
regulation of gene expression
positive regulation of vascular endothelial growth factor production
spinal cord motor neuron cell fate specification
spinal cord motor neuron differentiation
visceral motor neuron differentiation
trigeminal nerve development
pituitary gland development
neuron differentiation
pancreas development
axon regeneration
retinal ganglion cell axon guidance
positive regulation of insulin secretion
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of intracellular estrogen receptor signaling pathway
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of DNA binding
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate specification
mesenchymal cell differentiation
sensory system development
peripheral nervous system neuron development
peripheral nervous system neuron axonogenesis
negative regulation of inflammatory response
ventricular cardiac muscle tissue morphogenesis
pharyngeal system development
cardiac muscle cell myoblast differentiation
innervation
atrial septum morphogenesis
cardiac cell fate determination
cellular response to glucocorticoid stimulus
positive regulation of granulocyte colony-stimulating factor production
negative regulation of protein homodimerization activity
negative regulation of canonical Wnt signaling pathway
positive regulation of macrophage colony-stimulating factor production

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
bHLH transcription factor binding
sequence-specific DNA binding