50786

• Gene Symbol: Smad4
• Gene Name: SMAD family member 4
• Gene Aliases: Madh4
• Chromosome Location: Chr.18: 69627824 - 69657301 on Build Rnor_6.0
• UniGene ID: Rn.9774
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Smad4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_019275.2	NP_062148.1	2	329
GenBank mRNA	AB010954.1	-	2	329
	AF056002.1	-		401

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_005359, U44378, BC002379, AK290770.
This siRNA also targets the following transcripts in Mouse: NM_008540, GU072918, BC046584, GU072917, GU072919, and others.

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

branching involved in ureteric bud morphogenesis
response to hypoxia
in utero embryonic development
gastrulation with mouth forming second
kidney development
atrioventricular valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of cell proliferation involved in heart valve morphogenesis
cardiac septum development
brainstem development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
gastrulation
axon guidance
endoderm development
mesoderm development
cell proliferation
negative regulation of cell proliferation
anterior/posterior pattern specification
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
neural crest cell differentiation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell growth
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
somite rostral/caudal axis specification
regulation of transforming growth factor beta2 production
intracellular signal transduction
atrioventricular canal development
endothelial cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
developmental growth
neuron fate commitment
tissue morphogenesis
sebaceous gland development
formation of anatomical boundary
regulation of binding
regulation of hair follicle development
palate development
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
negative regulation of cell death
endocardial cell differentiation
response to transforming growth factor beta
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
collagen binding
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
filamin binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
SMAD binding
metal ion binding
protein heterodimerization activity
I-SMAD binding
R-SMAD binding