5140

• Gene Symbol: SREBF1
• Gene Name: sterol regulatory element binding transcription factor 1
• Gene Aliases: SREBP-1c, SREBP1, SREBP1a, bHLHd1
• Chromosome Location: Chr.17: 17811349 - 17837017 on Build GRCh38
• UniGene ID: Hs.592123
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SREBF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005291.2	NP_001005291.1	6, 7	1354
	NM_001321096.2	NP_001308025.1	5, 6	1126
	NM_004176.4	NP_004167.3	5, 6	1264
	XM_005256772.4	XP_005256829.1	5, 6	1264
	XM_017024970.1	XP_016880459.1	3, 4	547
GenBank mRNA	AB209609.1	-	3, 4	1686
	AB373958.1	-	5, 6	1070
	AB373959.1	-	5, 6	1004
	AK091131.1	-	5, 6	1093
	AK128320.1	-	3, 4	773
	AK293795.1	-	5, 6	964
	AK294800.1	-	6, 7	942
	AK297113.1	-	3, 4	678
	BC057388.1	-	5, 6	1255	5786483
	BC063281.1	-	6, 7	1329	5264244
	U00968.1	-	5, 6	1236

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001276707, NM_001276708, XM_008767879, AF286469, AF286470.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
regulation of heart rate by chemical signal
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
aging
circadian rhythm
cholesterol metabolic process
insulin receptor signaling pathway
lipid biosynthetic process
cellular response to starvation
response to glucose
positive regulation of triglyceride biosynthetic process
regulation of fatty acid metabolic process
lung development
positive regulation of histone deacetylation
regulation of protein stability
response to food
response to retinoic acid
response to progesterone
response to glucagon
response to drug
mRNA transcription from RNA polymerase II promoter
fat cell differentiation
positive regulation of cholesterol biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
response to cAMP
cellular response to fatty acid
regulation of mitophagy
regulation of protein targeting to mitochondrion

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
protein complex binding
sterol response element binding
protein dimerization activity