52279

• Gene Symbol: Pdx1
• Gene Name: pancreatic and duodenal homeobox 1
• Gene Aliases: Idx1, Ipf1, Stf1
• Chromosome Location: Chr.12: 9496044 - 9501211 on Build Rnor_6.0
• UniGene ID: Rn.54603
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pdx1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_022852.3	NP_074043.3	2	540
GenBank mRNA	U04833.1	-	2	540

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: AF049893.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
nitric oxide mediated signal transduction
central nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
response to glucose
response to iron(II) ion
response to chlorate
organ senescence
positive regulation of cell death
response to organic cyclic compound
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
response to drug
glucose homeostasis
response to leucine
response to alkaloid
positive regulation of DNA binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
response to glucocorticoid
detection of glucose
transdifferentiation
response to fatty acid
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
protein complex binding
sequence-specific DNA binding
protein heterodimerization activity