53607

• Gene Symbol: Egfr
• Gene Name: epidermal growth factor receptor
• Gene Aliases: ERBB1, ErbB-1, Errp
• Chromosome Location: Chr.14: 99919485 - 100104136 on Build Rnor_6.0
• UniGene ID: Rn.37227
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Egfr
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_031507.1	NP_113695.1	1, 2	239
GenBank mRNA	HM801041.1	-	1, 2	204
	HM801042.1	-	1, 2	204
	M37394.2	-	1, 2	239

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_005228, NM_201283, NM_201284, NM_201282, AY698024, and others.

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
cell morphogenesis
liver development
embryonic placenta development
positive regulation of protein phosphorylation
hair follicle development
translation
response to osmotic stress
response to oxidative stress
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
salivary gland morphogenesis
learning or memory
circadian rhythm
cell proliferation
positive regulation of cell proliferation
epidermis development
magnesium ion homeostasis
response to organic cyclic compound
diterpenoid metabolic process
single organismal cell-cell adhesion
peptidyl-tyrosine phosphorylation
cerebral cortex cell migration
signal transduction by protein phosphorylation
lung development
positive regulation of cell migration
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to estradiol
positive regulation of superoxide anion generation
response to cobalamin
response to hydroxyisoflavone
response to lipid
positive regulation of catenin import into nucleus
intracellular signal transduction
cellular response to drug
regulation of cell proliferation
negative regulation of protein catabolic process
positive regulation of phosphorylation
ovulation cycle
hydrogen peroxide metabolic process
negative regulation of apoptotic process
positive regulation of MAP kinase activity
tongue development
positive regulation of nitric oxide biosynthetic process
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of vasoconstriction
positive regulation of vasodilation
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
astrocyte activation
positive regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of inflammatory response
regulation of peptidyl-tyrosine phosphorylation
regulation of nitric-oxide synthase activity
response to calcium ion
positive regulation of protein kinase B signaling
positive regulation of synaptic transmission, glutamatergic
morphogenesis of an epithelial fold
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
cellular response to dexamethasone stimulus

Function(s)

glycoprotein binding
chromatin binding
protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
signal transducer activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
receptor binding
integrin binding
protein binding
ATP binding
kinase activity
enzyme binding
protein kinase binding
protein phosphatase binding
nitric-oxide synthase regulator activity
ubiquitin protein ligase binding
identical protein binding
protein heterodimerization activity
epidermal growth factor binding
actin filament binding