53950

• Gene Symbol: Eif2ak3
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 3
• Gene Aliases: PEK
• Chromosome Location: Chr.4: 98648507 - 98709695 on Build Rnor_6.0
• UniGene ID: Rn.24897
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Eif2ak3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_031599.2	NP_113787.1	2, 3	642
	XM_006236623.1	XP_006236685.1	2, 3	160
	XM_006236624.2	XP_006236686.1	2, 3	680
	XM_008762977.1	XP_008761199.1	1, 2	274
GenBank mRNA	AF096835.1	-	2, 3	643

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_010121, AF076681, BC054809.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

skeletal system development
ossification
angiogenesis
chondrocyte development
translation
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
ER overload response
endoplasmic reticulum organization
lactation
positive regulation of signal transduction
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
regulation of fatty acid metabolic process
calcium-mediated signaling
bone mineralization
endoplasmic reticulum unfolded protein response
pancreas development
endocrine pancreas development
negative regulation of myelination
negative regulation of translation in response to stress
negative regulation of translational initiation in response to stress
positive regulation of protein binding
SREBP signaling pathway
response to endoplasmic reticulum stress
cellular response to glucose starvation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription from RNA polymerase I promoter
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
protein homooligomerization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Function(s)

protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
ATP binding
enzyme binding
protein phosphatase binding
identical protein binding