54649

• Gene Symbol: Akt1
• Gene Name: v-akt murine thymoma viral oncogene homolog 1
• Gene Aliases: Akt
• Chromosome Location: Chr.6: 137218398 - 137239970 on Build Rnor_6.0
• UniGene ID: Rn.11422
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Akt1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_033230.2	NP_150233.1	12	1353
	XM_006240631.2	XP_006240693.1	13	1852
	XM_008764918.1	XP_008763140.1	12	3399
GenBank mRNA	D30040.1	-	12	1357

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001014431, NM_001014432, NM_005163, BX648205, AK131465, and others.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
osteoblast differentiation
maternal placenta development
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
glycogen metabolic process
glycogen biosynthetic process
regulation of glycogen biosynthetic process
glucose metabolic process
translation
regulation of translation
protein phosphorylation
negative regulation of protein kinase activity
activation-induced cell death of T cells
inflammatory response
response to oxidative stress
signal transduction
germ cell development
aging
insulin receptor signaling pathway
apoptotic mitochondrial changes
response to hormone
negative regulation of autophagy
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of sodium ion transport
positive regulation of glucose metabolic process
negative regulation of endopeptidase activity
regulation of neuron projection development
glucose transport
phosphorylation
protein ubiquitination
peptidyl-serine phosphorylation
cell projection organization
protein catabolic process
hyaluronan metabolic process
positive regulation of cell growth
regulation of cell migration
regulation of myelination
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
lipopolysaccharide-mediated signaling pathway
negative regulation of fatty acid beta-oxidation
response to food
positive regulation of cellular protein metabolic process
peripheral nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
regulation of protein localization
positive regulation of peptidyl-serine phosphorylation
response to fluid shear stress
intracellular signal transduction
cellular response to decreased oxygen levels
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of nitric oxide biosynthetic process
positive regulation of fat cell differentiation
positive regulation of glycogen biosynthetic process
negative regulation of cell size
negative regulation of proteolysis
positive regulation of vasoconstriction
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
negative regulation of JNK cascade
positive regulation of lipid biosynthetic process
insulin-like growth factor receptor signaling pathway
positive regulation of nitric-oxide synthase activity
positive regulation of sequence-specific DNA binding transcription factor activity
striated muscle cell differentiation
response to growth hormone
glycogen cell differentiation involved in embryonic placenta development
labyrinthine layer blood vessel development
response to UV-A
cellular response to mechanical stimulus
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
cellular response to prostaglandin E stimulus
cellular response to organic cyclic compound
cellular response to hypoxia
positive regulation of establishment of protein localization to plasma membrane
negative regulation of release of cytochrome c from mitochondria
cellular response to granulocyte macrophage colony-stimulating factor stimulus
execution phase of apoptosis
cellular response to peptide
response to insulin-like growth factor stimulus

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein kinase C binding
protein binding
ATP binding
phosphatidylinositol-3,4,5-trisphosphate binding
kinase activity
enzyme binding
protein kinase binding
nitric-oxide synthase regulator activity
identical protein binding
phosphatidylinositol-3,4-bisphosphate binding
protein phosphatase 2A binding
14-3-3 protein binding