5533

• Gene Symbol: XBP1
• Gene Name: X-box binding protein 1
• Gene Aliases: TREB-5, TREB5, XBP-1, XBP2
• Chromosome Location: Chr.22: 28794560 - 28800572 on Build GRCh38
• UniGene ID: Hs.437638
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: XBP1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001079539.1	NP_001073007.1	6	1750
	NM_005080.3	NP_005071.2	5	1776
GenBank mRNA	AB076383.1	-	5	1736
	AB076384.1	-	6	1710
	AK093842.1	-	2	2128
	BC000938.1	-	5	1733	3449394
	BC012841.1	-	5	1760	3856898
	BC015709.1	-	5	1669
	M31627.1	-	5	1748

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001271731, NM_001004210, FQ230367, FQ232289, FQ225483, and others.
This siRNA also targets the following transcripts in Mouse: NM_001271730, NM_013842, AF027963, AK205453, AF443192, and others.

Gene Ontology Categories:

Process(es)

angiogenesis
liver development
endothelial cell proliferation
positive regulation of immunoglobulin production
transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
fatty acid biosynthetic process
autophagy
immune response
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
muscle organ development
regulation of autophagy
negative regulation of myotube differentiation
protein transport
endoplasmic reticulum unfolded protein response
exocrine pancreas development
protein destabilization
cellular response to nutrient
cellular response to insulin stimulus
cellular triglyceride homeostasis
IRE1-mediated unfolded protein response
ATF6-mediated unfolded protein response
cellular response to glucose starvation
cholesterol homeostasis
negative regulation of apoptotic process
positive regulation of MHC class II biosynthetic process
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron development
positive regulation of immunoglobulin secretion
fatty acid homeostasis
sterol homeostasis
adipose tissue development
epithelial cell maturation involved in salivary gland development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-4
cellular response to peptide hormone stimulus
positive regulation of plasma cell differentiation
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of proteasomal protein catabolic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of lactation
response to insulin-like growth factor stimulus
positive regulation of hepatocyte proliferation
positive regulation of interleukin-6 secretion

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
phosphatidylinositol 3-kinase regulatory subunit binding
histone deacetylase binding
protein heterodimerization activity