594 Validated

• Gene Symbol: EIF2AK3
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 3
• Gene Aliases: PEK, PERK, WRS
• Chromosome Location: Chr.2: 88556740 - 88627576 on Build GRCh38
• UniGene ID: Hs.591589
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EIF2AK3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_004836.6	NP_004827.4	1, 2	618
	XM_017005376.1	XP_016860865.1	1, 2	314
GenBank mRNA	AF110146.1	-	1, 2	385
	AF193339.1	-	1, 2	615
	AK128659.1	-	2, 3	371
	AK315287.1	-	1, 2	523
	BC126354.1	-	1, 2	412	8992070
	BC126356.1	-	1, 2	409	8992072

More Information

Matching Taqman Gene Expression Assay:

Hs00178128_m1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

skeletal system development
ossification
angiogenesis
chondrocyte development
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
ER overload response
endoplasmic reticulum organization
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
peptidyl-serine phosphorylation
calcium-mediated signaling
insulin secretion
bone mineralization
endoplasmic reticulum unfolded protein response
endocrine pancreas development
negative regulation of myelination
negative regulation of translational initiation in response to stress
cellular response to amino acid starvation
response to endoplasmic reticulum stress
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
positive regulation of transcription from RNA polymerase I promoter
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
protein homooligomerization
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
cellular response to cold
positive regulation of protein localization to nucleus
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
response to manganese-induced endoplasmic reticulum stress

Function(s)

protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
protein binding
ATP binding
enzyme binding
protein phosphatase binding
identical protein binding
protein homodimerization activity
Hsp90 protein binding