59488

• Gene Symbol: Twist1
• Gene Name: twist family bHLH transcription factor 1
• Gene Aliases: Twist
• Chromosome Location: Chr.6: 53401241 - 53403235 on Build Rnor_6.0
• UniGene ID: Rn.161904
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Twist1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053530.2	NP_445982.1	1	615
GenBank mRNA	AF266260.1	-	1	110
	BC166412.1	-	1	745	9033082

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_000474, X99268, BC036704.
This siRNA also targets the following transcripts in Mouse: NM_011658, BC083139, BC033434, M63650.

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
neuron migration
neural tube closure
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of phosphatidylinositol 3-kinase signaling
cell differentiation
embryonic limb morphogenesis
regulation of bone mineralization
positive regulation of fatty acid beta-oxidation
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
negative regulation of histone phosphorylation
negative regulation of histone acetylation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
hindlimb morphogenesis
negative regulation of peroxisome proliferator activated receptor signaling pathway
odontogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of molecular function
negative regulation of cell differentiation
negative regulation of osteoblast differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of skeletal muscle tissue development
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
positive regulation of epithelial cell proliferation
palate development
bone development
cranial suture morphogenesis
embryonic camera-type eye formation
eyelid development in camera-type eye
cardiac neural crest cell development involved in outflow tract morphogenesis
cellular response to growth factor stimulus
cellular response to hypoxia
positive regulation of monocyte chemotactic protein-1 production
positive regulation of cell motility
negative regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
negative regulation of cellular senescence
positive regulation of interleukin-6 secretion
negative regulation of double-strand break repair
cell proliferation involved in heart valve development
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
molecular_function
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
E-box binding