60001

• Gene Symbol: App
• Gene Name: amyloid beta (A4) precursor protein
• Gene Aliases: Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp
• Chromosome Location: Chr.16: 84954436 - 85173952 on Build GRCm38
• UniGene ID: Mm.277585
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: App
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001198823.1	NP_001185752.1	2	329
	NM_001198824.1	NP_001185753.1	2	329
	NM_001198825.1	NP_001185754.1	2	329
	NM_001198826.1	NP_001185755.1	2	329
	NM_007471.3	NP_031497.2	2	329
GenBank mRNA	AK128971.1	-	2	338
	AK133639.1	-	2	326
	AK147543.1	-	2	365
	AK148439.1	-	2	201
	AK159245.1	-	2	338
	AK159352.1	-	2	336
	AK159718.1	-	2	315
	AK161976.1	-	2	305
	AK194233.1	-	1	103
	AK218334.1	-	2	148
	AY267348.1	-	2	180
	BC070409.1	-	2	325	5708093
	M18373.1	-	2	318
	U84012.1	-	2	318
	X59379.1	-	2	248

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001204303, NM_001204302, NM_001136131, NM_201413, NM_201414, and others.
This siRNA also targets the following transcripts in Rat: NM_019288, XM_006248010, XM_006248009, XM_006248011, XM_006248008, and others.

Panther Classification:

Molecular Function -

protease inhibitor

Gene Ontology Categories:

Process(es)

suckling behavior
mRNA polyadenylation
regulation of translation
protein phosphorylation
cellular copper ion homeostasis
endocytosis
apoptotic process
response to oxidative stress
cell adhesion
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
nervous system development
axonogenesis
mating behavior
locomotory behavior
axo-dendritic transport
cholesterol metabolic process
adult locomotory behavior
visual learning
negative regulation of peptidase activity
regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of peptidase activity
positive regulation of G2/M transition of mitotic cell cycle
axon midline choice point recognition
neuron remodeling
dendrite development
extracellular matrix organization
forebrain development
neuron projection development
ionotropic glutamate receptor signaling pathway
regulation of multicellular organism growth
regulation of protein binding
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting in absence of injury
regulation of synapse structure or activity
neuromuscular process controlling balance
synaptic growth at neuromuscular junction
protein homooligomerization
neuron apoptotic process
smooth endoplasmic reticulum calcium ion homeostasis

Function(s)

DNA binding
serine-type endopeptidase inhibitor activity
receptor binding
protein binding
heparin binding
peptidase activator activity
enzyme binding
peptidase inhibitor activity
acetylcholine receptor binding
identical protein binding
metal ion binding
transition metal ion binding
PTB domain binding
growth factor receptor binding