602

• Gene Symbol: MTOR
• Gene Name: mechanistic target of rapamycin
• Gene Aliases: FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
• Chromosome Location: Chr.1: 11106531 - 11262551 on Build GRCh38
• UniGene ID: Hs.338207
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MTOR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_004958.3	NP_004949.1	3	303
	XM_005263438.2	XP_005263495.1	3	310
	XM_011541166.2	XP_011539468.1	3	303
	XM_017000901.1	XP_016856390.1	2	163
	XM_017000902.1	XP_016856391.1	3	303
GenBank mRNA	AB209995.1	-	3	284
	AK304273.1	-	3	292
	BC117166.1	-	2	200	40125717
	BP250183.1	-	3	308
	L34075.1	-	3	261
	U88966.1	-	3	261

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019906, L37085, U11681.
This siRNA also targets the following transcripts in Mouse: NM_020009, BC043920, AK036004, AK172584, CJ130100, and others.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
heart morphogenesis
heart valve morphogenesis
regulation of glycogen biosynthetic process
energy reserve metabolic process
'de novo' pyrimidine nucleobase biosynthetic process
DNA repair
protein phosphorylation
response to stress
cell cycle arrest
signal transduction
germ cell development
brain development
cell aging
response to nutrient
long-term memory
visual learning
post-embryonic development
negative regulation of autophagy
positive regulation of lamellipodium assembly
positive regulation of gene expression
positive regulation of myotube differentiation
positive regulation of neuron maturation
negative regulation of muscle atrophy
cell growth
macroautophagy
negative regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
spinal cord development
protein catabolic process
positive regulation of actin filament polymerization
T cell costimulation
negative regulation of protein ubiquitination
ruffle organization
regulation of myelination
cellular response to nutrient levels
TOR signaling
regulation of fatty acid beta-oxidation
regulation of response to food
response to insulin
regulation of actin cytoskeleton organization
social behavior
multicellular organism growth
growth
wound healing
response to cocaine
regulation of GTPase activity
response to amino acid
response to morphine
regulation of carbohydrate utilization
positive regulation of nitric oxide biosynthetic process
regulation of osteoclast differentiation
positive regulation of translation
negative regulation of cell size
regulation of protein kinase activity
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
positive regulation of lipid biosynthetic process
phosphatidylinositol-mediated signaling
mRNA stabilization
positive regulation of smooth muscle cell proliferation
positive regulation of oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
voluntary musculoskeletal movement
positive regulation of stress fiber assembly
negative regulation of NFAT protein import into nucleus
positive regulation of protein kinase B signaling
cardiac muscle cell development
cardiac muscle contraction
maternal process involved in female pregnancy
positive regulation of glial cell proliferation
positive regulation of dendritic spine development
positive regulation of cell growth involved in cardiac muscle cell development
cellular response to hypoxia
regulation of brown fat cell differentiation
regulation of membrane permeability
regulation of cellular response to heat
positive regulation of neuron death
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of eating behavior
positive regulation of cholangiocyte proliferation
positive regulation of sensory perception of pain
negative regulation of cholangiocyte apoptotic process
positive regulation of granulosa cell proliferation
positive regulation of skeletal muscle hypertrophy
negative regulation of iodide transmembrane transport

Function(s)

RNA polymerase III type 1 promoter DNA binding
RNA polymerase III type 2 promoter DNA binding
RNA polymerase III type 3 promoter DNA binding
TFIIIC-class transcription factor binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein kinase binding
protein domain specific binding
ribosome binding
phosphoprotein binding