6126

• Gene Symbol: MCL1
• Gene Name: BCL2 family apoptosis regulator
• Gene Aliases: BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
• Chromosome Location: Chr.1: 150574551 - 150579738 on Build GRCh38
• UniGene ID: Hs.632486
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MCL1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001197320.1	NP_001184249.1	2	339
	NM_021960.4	NP_068779.1	1	798
	NM_182763.2	NP_877495.1	1	798
GenBank mRNA	AF118124.1	-	1	639
	AF118276.1	-	1	48
	AF118277.1	-	1	48
	AF118278.1	-	1	48
	AF203373.1	-	1	590
	AK294462.1	-	2	370
	AK297217.1	-	2	334
	AK300499.1	-	2	444
	AK304775.1	-	2	480
	AK312508.1	-	1	670
	AK316267.1	-	2	626
	BC017197.2	-	1	644	3138465
	BC071897.1	-	1	646	6586159
	BC107735.1	-	1	661	4770487
	BT006640.1	-	1	590
	FJ917536.1	-	2	131
	L08246.1	-	1	650

More Information

Gene Ontology Categories:

Process(es)

cell fate determination
multicellular organism development
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
cellular homeostasis
response to cytokine
negative regulation of apoptotic process
protein transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of anoikis
regulation of response to DNA damage stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

protein binding
protein channel activity
protein homodimerization activity
protein heterodimerization activity
BH3 domain binding