61527

• Gene Symbol: Ezh2
• Gene Name: enhancer of zeste homolog 2 (Drosophila)
• Gene Aliases: Enx-1, Enx1h, KMT6, mKIAA4065
• Chromosome Location: Chr.6: 47530274 - 47595340 on Build GRCm38
• UniGene ID: Mm.246688
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ezh2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001146689.1	NP_001140161.1	18	2180
	NM_007971.2	NP_031997.2	18	2192
GenBank mRNA	AK157853.1	-	18	2193
	AK220174.1	-	18	2147
	BC003772.1	-	18	2101	3492110
	BC016391.1	-	18	2114	3586689
	BC079538.1	-	18	2131	6817366
	U52951.1	-	18	2182

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001134979, XM_006236404, XM_006236408, XM_006236403, XM_006236405, and others.

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
regulation of gliogenesis
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
chromatin modification
histone methylation
peptidyl-lysine methylation
cerebellar cortex development
methylation
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of cell proliferation
regulation of circadian rhythm
positive regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of GTPase activity
negative regulation of epidermal cell differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
rhythmic process
regulation of neurogenesis
negative regulation of striated muscle cell differentiation
cellular response to hydrogen peroxide
G1 to G0 transition
histone H3-K27 methylation
protein localization to chromatin
positive regulation of protein serine/threonine kinase activity
positive regulation of dendrite development
negative regulation of G1/S transition of mitotic cell cycle

Function(s)

regulatory region DNA binding
core promoter binding
chromatin binding
RNA binding
protein binding
methyltransferase activity
protein-lysine N-methyltransferase activity
transferase activity
histone-lysine N-methyltransferase activity
chromatin DNA binding
histone methyltransferase activity
sequence-specific DNA binding