61937

• Gene Symbol: Gclm
• Gene Name: glutamate-cysteine ligase, modifier subunit
• Gene Aliases: AI649393, Gcmc, Glclr
• Chromosome Location: Chr.3: 122245557 - 122267215 on Build GRCm38
• UniGene ID: Mm.292676
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Gclm
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008129.4	NP_032155.1	2, 3	628
GenBank mRNA	AK028236.1	-	2, 3	594
	AK172387.1	-	2, 3	569
	BC132404.1	-	3, 4	315	40130681
	BC138783.1	-	3, 4	337	8861805
	CT010256.1	-	2, 3	199
	U95053.1	-	2, 3	239

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017305, L22191, DQ266366, S65555, BC078867.

Panther Classification:

Molecular Function -

ligase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
positive regulation of glutamate-cysteine ligase activity
response to drug
negative regulation of neuron apoptotic process
regulation of catalytic activity
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

glutamate-cysteine ligase activity
enzyme regulator activity
glutamate-cysteine ligase catalytic subunit binding
protein heterodimerization activity