62397

• Gene Symbol: Irak1
• Gene Name: interleukin-1 receptor-associated kinase 1
• Gene Aliases: AA408924, IRAK, IRAK-1, IRAK1-S, Il1rak, Plpk, mPLK
• Chromosome Location: Chr.X: 74013914 - 74023921 on Build GRCm38
• UniGene ID: Mm.38241
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Irak1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001177973.1	NP_001171444.1	5	837
	NM_001177974.1	NP_001171445.1	5	834
	NM_001177975.1	NP_001171446.1	5	834
	NM_001177976.1	NP_001171447.1	5	834
	NM_008363.2	NP_032389.2	5	834
GenBank mRNA	AB088370.1	-	5	661
	AF103876.1	-	5	834
	AK045958.1	-	5	743
	AK052933.1	-	4	819
	AK143694.1	-	5	745
	AK144879.1	-	5	743
	AK210148.1	-	1	101
	AY184362.1	-	5	834
	AY184363.1	-	5	834
	AY184364.1	-	5	834
	BC004778.1	-	5	829	3257579
	U56773.2	-	5	658

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001127555, XM_006229598, BC166780.

Gene Ontology Categories:

Process(es)

regulation of cytokine-mediated signaling pathway
immune system process
protein phosphorylation
signal transduction
activation of NF-kappaB-inducing kinase activity
JNK cascade
phosphorylation
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to peptidoglycan
response to lipopolysaccharide
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
cellular response to heat
intracellular signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
innate immune response
negative regulation of transcription, DNA-templated
protein autophosphorylation
positive regulation of smooth muscle cell proliferation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
interleukin-1-mediated signaling pathway
response to interleukin-1
negative regulation of cholesterol efflux

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
interleukin-1 receptor binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
heat shock protein binding
protein homodimerization activity
protein heterodimerization activity